IADR Abstract Archives

Immunoexpression of galectin-3 and HIF1 in ameloblastomas and its role in invasiveness

Objectives: The aim of the present study is to elucidate the expression of hypoxia related proteins galectin-3 and HIF1 in conventional and unicystic ameloblastomas in order to relate them with the process of invasion in this neoplasm.
Methods: Seventy-two ameloblastoma cases were included for the study. Immunohistochemistry technique was performed against galectin-3 and HIF1.
Results: Positive expression for galectin-3 was observed in 40% of ameloblastoma cases (38% conventional), intense expression was related with ameloblastomas presenting squamous metaplasia (38%). Positive expression for HIF1 was observed in 55% of the sample (61% conventional ameloblastoma). Areas with squamous metaplasia also showed intense positivity for HIF1.
Conclusions: Considering the intracellular positivity of galectin-3 (nuclear and/or cytoplasmic), found in almost one-half of the samples, we could suggest its possible role in the tumor behavior. Immunolocalization, predominantly cytoplasmic, in central areas of the follicular epithelium with squamous metaplasia could be interpreted as a possible response associated to stress and hypoxia, consistent with the presence of HIF1 in the same area.
Uruguayan Division Meeting
2019 Uruguayan Division Meeting (Montevideo, Uruguay)
Montevideo, Uruguay
2019

Oral Medicine & Pathology Research
  • Pereira, Vanesa  ( Universidad de la Republica , Montevideo , Uruguay )
  • SÁnchez, Celeste  ( Universidad de la Republica , Montevideo , Uruguay )
  • Vigil, Gabriela  ( Universidad de la Republica , Montevideo , Uruguay )
  • Arocena, Miguel  ( FACULTAD DE ODONTOLOGIA , MONTEVIDEO , Uruguay )
  • Bologna Molina, Ronell  ( Universidad de la Republica , Montevideo , Uruguay )
  • NONE
    Oral Session
    Oral Presentations at 2019 Uruguayan Division Meeting