Biochemical parameters in saliva in relation with consumption of anovulistatics

Objectives: to know if consumption of anovulistatics has an influence in pH levels, buffer capacity, amylase and proteins in saliva. Methods: a random sample of 180 women which 88 of them are not consuming anovulistatics at least from more than two years, and 98 were taking for a period of more than 5 year. Samples of stimulated saliva are taken in both groups and determine pH with electrode, buffer capacity by Ericsson technique, amylase by kinetic technique and proteins by spectrofotometry. Results: General parameters in both groups were similar. Average pH anovulistatics 7,24, controls 7,16. pH > 6,81 anovulistatics 90,5% controls 85,2%, buffer capacity ≥5: anovulistatics 63,8%, controls 47,6%. Buffer capacity < 4: anovulistatics 25,6 %, controls 34,1 %, Average buffer capacity: anovulistatics 5,36, controls 5,12, amylase production 1000 u/ml average anovulistatics 165,5, controls 177,8; Proteins expressed in µg/ml, anovulistatics 1,27; controls 1,28. There is better buffer capacity and higher pH in the group of anovulistatics perhaps due to the increase of saliva flow, added to is associated to a bigger production of bicarbonate. Contrasting this with the fact that during pregnancy estrogenic and progesterone production rates increase but buffer capacity decrease and must be reminded that the amount of these products is very low in anovulistatics in relation of pregnancy. Conclusions: The intake of anovulistatics could be associated with better pH level and buffer capacity, without changing amylase and proteins in saliva.