Effect of Antiinfective Therapy on Peri-implant Crevicular Fluid PGE2 level

Objectives: The aim of this study was to evaluate the effect of antiinfective therapy on peri-implant crevicular fluid (PICF) prostaglandin E2 (PGE2) level and its possible association with clinical parameters. Methods: A total of 25 endosseous root-form dental implants in 14 patients were clinically examined by plaque index (PI), gingival index (GI), clinical attachment level (CAL), bleeding on probing (BOP) and probing depth (PD). PICF was collected by Periopaper strips inserted in crevice for 30sec. The volume of PICF was determined by Periotron8000. Then, antiinfective therapy was performed. PICF sampling and clinical measurements were recorded at baseline, 1 month and 9 month after therapy. Assay for PGE2 was carried out by commercial EIA kit. PICF PGE2 levels were defined both as concentration (ng/mL) and total amount per unit time (ng/30sec). Results: Following antiinfective therapy, mean PI, GI, BOP scores and PD were significantly reduced at 1 and 9 months, when compared to baseline measurements (p<0.05). However, PICF PGE2 levels were not changed (p>0.05). Moreover, we were not able to determine any significant association between clinical parameters and PICF PGE2 levels in the course of study. Conclusions: Based on the data obtained from this study, we conclude that antiinfective therapy has no effect on PGE2 levels in peri-implant crevicular fluid and it does not reflect the clinical condition around dental implants. Partly supported by Selcuk University Scientific Research Fund.