The dentition is often considered to reflect the functional status of chewing and nutrition. Objectives: The aim of the study was to investigate the relationship between aging and tooth loss, and to disclose which factors are the most important for extraction of teeth in Syria. Methods: Tooth loss and need for extraction were explored for a total of 2355 dental patients (1250 males and 1105 females) aged 18 years and above. Results: complete tooth loss in patients aged 35 years and older was 21.3%, where it was 54.7% for patients aged 65 years and older. The mean number of remaining teeth in dentate patients aged 35years and older was 17.8%; where the mean number of remaining teeth decreased in each older group. In 35-44-year-old patients, only 8.26% hat not lost at least one permanent tooth. There was no significant difference as for the average of lost teeth between males and females (p>0.05). The main reason for extraction was the caries or one of its complications (52.08%), and then came the second degree periodontal cases (42.83%). Females lost most of their teeth by caries at a higher rate (54.96%) than males (48.15%). Conclusion: This study provides evidence that the Tooth loss remains a substantial problem in Syria, and the caries remained a major cause of tooth loss due to the higher prevalence of this condition. There is no doubt a correlation between aging and tooth loss.