growth factor versus natural model as an antidiabetic prophylactic agent

Objectives: The objective of this study was to evaluate the anticipated effect of growth factor versus Zamzam water as natural model on oral mucosal tissues of diabetic albino rats
Methods: Eighteen male albino rats were selected and divided into four groups. Group I
(control group) received no drugs, while rats of group II (diabetic group) received a single dose of alloxan
intraperitoneal injection, rats of group III diabetic and received zamzam water , group IV receving epidermal grwoth factor injection. All rats were
sacrificed oral mucosa was dissected and processed for hematoxylin & eosin and transmission electron
microscopy evaluation.
Results: The diabetic group showed histological & ultrastructural changes in the
oral epithelium and underlying lamina propria, a condition which almost restored to normal in zamzam
treated group. and nearly restorted in epidermal growth factor group
Conclusions: Zamzam water provides safer alternative nutritional strategy in restoring the
integrity of the damaged epithelium of the oral mucosal tissues after degenerative effect of DM. causing
improvement of the damaged epithelium and
lamina propria rather than epidermal grwoth factor administration .