IADR Abstract Archives
Periodontitis and its association with preeclampsia
Objectives: Periodontitis is a non-communicable disease with a multifactorial aetiology. It is one of the two major oral conditions contributing to the global burden of chronic diseases affecting up to 90% of the population. Periodontitis is an inflammatory disease which affects the supporting tissues of the teeth that leads to progressive destruction of the connective tissue attachment and bone loss.
Preeclampsia is a pregnancy-specific disorder that affects both mother and her foetus, and it is characterized by an increase in systolic arterial pressure (>140 mmHg) and diastolic pressure (>90 mmHg) on two separate occasions and proteinuria (>300 mg/24 hr), after 20 weeks of gestation.
It has been reported that women with periodontitis during pregnancy may have transient bacteraemia of their oral bacteria to the maternal and fetal blood circulation. This leads to placental inflammation resulting in increased oxidative stress early in pregnancy which may cause placental abnormalities and the clinical manifestations of preeclampsia.
Aim
To determine whether there is a significant association between periodontitis, which is associated with the release of pro-inflammatory cytokines and preeclampsia in the Western Cape, South Africa.
Objectives
To determine the periodontal status of pregnant women.
To determine if there is any significant difference in periodontal status between the two groups.
To determine the levels of inflammatory mediators of both groups using RT-PCR.
To determine if there is a relation between inflammatory mediators and periodontal status.
To determine if there is any relation between periodontitis and preeclampsia.
Methods: This is a case-control study in which 200 pregnant women were periodontally assessed and blood drawn to determine inflammatory cytokines using Real-time PCR, 100 with a confirmed diagnosis of pre-eclampsia and 100 normotensive pregnant women.
Results: Ethics Number: BM19/1/21
There was an associated between periodontitis and Preeclampsia.
Conclusions: We envisage that the outcome of this study will highlight the importance of dental referrals and dental intervention for pregnant women and facilitate the allocation of resources in terms of improving the dental management of pregnant women.
Preeclampsia is a pregnancy-specific disorder that affects both mother and her foetus, and it is characterized by an increase in systolic arterial pressure (>140 mmHg) and diastolic pressure (>90 mmHg) on two separate occasions and proteinuria (>300 mg/24 hr), after 20 weeks of gestation.
It has been reported that women with periodontitis during pregnancy may have transient bacteraemia of their oral bacteria to the maternal and fetal blood circulation. This leads to placental inflammation resulting in increased oxidative stress early in pregnancy which may cause placental abnormalities and the clinical manifestations of preeclampsia.
Aim
To determine whether there is a significant association between periodontitis, which is associated with the release of pro-inflammatory cytokines and preeclampsia in the Western Cape, South Africa.
Objectives
To determine the periodontal status of pregnant women.
To determine if there is any significant difference in periodontal status between the two groups.
To determine the levels of inflammatory mediators of both groups using RT-PCR.
To determine if there is a relation between inflammatory mediators and periodontal status.
To determine if there is any relation between periodontitis and preeclampsia.
Methods: This is a case-control study in which 200 pregnant women were periodontally assessed and blood drawn to determine inflammatory cytokines using Real-time PCR, 100 with a confirmed diagnosis of pre-eclampsia and 100 normotensive pregnant women.
Results: Ethics Number: BM19/1/21
There was an associated between periodontitis and Preeclampsia.
Conclusions: We envisage that the outcome of this study will highlight the importance of dental referrals and dental intervention for pregnant women and facilitate the allocation of resources in terms of improving the dental management of pregnant women.