Effects of calcitonin on osteoclast during mouse teeth eruption

Objective: To observe calcitonin on osteoclast during mouse teeth eruption and analyze the mechanism. Methods: Ten brood pups after 3d birth were distributed randomly to control and calcitonin groups. The mouses in calcitonin group were injected with calcitonin for 3days (1U /100g/day), 7days after injection the pups were sacrificed and mandible were taken out. The number of the osteoclasts was detected with tartrate°ªresistance acid phosphatase(TRAP)staining£®Immunohistochemistry was used to examine the expressions of RANKL£®Results: The number of osteoclasts in calcitonin group was less than in control group. (P <0.05) There was significant difference for RANKL proteinum between calcitonin and control groups. Conclusion: Calcitonin could inhibit osteoclast during mouse teeth eruption which will provide reference to investigation about tooth eruption.