The effect of molarless on cholinergic fibers in sensory cortex

Objective: Previous evidence suggests that molarless can deficit the basal forebrain cholinergic system. We investigated whether molarless affect cholinergic system in the primary somatic sensory areas. Methods: Forty rats were divided into molars extraction aged group (18 months),control aged group (18 months), molars extraction young group (3 months)and control young group (3 months).2 months after molars extraction on the left side, the quantitative analysis AchE-positive fibers in layers¢ñ, ¢ó and ¢ô within Brodmann 2 and 3 areas of all experimental animals was carried out . Results: The density of AchE¨C positive fibers in layers¢ñ, ¢ó and ¢ô within Brodmann 2 and 3 areas in control aged groups were significantly lower than those in control young group(P<0.01). The density of AchE¨C positive fibers in layers¢ñ, ¢ó and ¢ô within Brodmann 2 area and in layers ¢ñand ¢ó within Brodmann 3 area in molars extraction aged group were significantly lower than those in control aged group(P<0.01).There was no stactistic difference between molars extraction young and control young groups. Conclusion: These data indicate that unilateral molarless can accelerated degeneration on cholinergic system in primary somatic sensory area of aged rats.