Effects of nonsurgical periodontal therapy on CRP and sICAM-1 levels

Objectives: The aim of the present study was to determine whether the presence of chronic periodontitis and subsequent periodontal treatment could influence the serum levels of C-reactive protein (CRP) and soluble intercellular adhesion molecule-1 (sICAM-1). Methods: Sera were obtained from 22 patients with moderate/severe chronic periodontitis at the baseline examination and at reassessment after non-surgical periodontal therapy. As a control, sera were also obtained from 16 subjects without periodontitis. CRP and sICAM-1 were measured by sensitive enzyme-linked immunosorbent assay.Results: The levels of CRP and sICAM-1 in the sera of chronic periodontitis were significantly higher than that in health control subjects. Periodontal status demonstrated a significant improvement in all patients following the treatment. CRP and sICAM-1 concentration were reduced significantly with improvement of the periodontal condition following treatment and approached that of control subjects. Conclusions: The study shows that periodontal disease significantly affects the serum levels of CRP and sICAM-1.