IgG antibody titers to Pg in patients with aggressive periodontitis

Objectives: The aims of this study were to measure the IgG antibody titers to Pg in serum with GAgP subjects; to study the association of the IgG titers to Pg with periodontal status (alveolar bone loss) to analyze the host-related determinants ( age, gender) and environmental factors (smoking) on IgG titers to Pg in patients with aggressive periodontitis. Methods: (1)91 AgP subjects, 27.6 years old in average; females 56, males 35, and 14 male-smokers; 35 healthy subjects, as a control group, 29.4 years old in average, males 10 and females 25; (2) Questionnaire, clinical evaluations and assessments of alveolar bone loss were made (3) To categorize patients into two groups: 1)Severe AgP group, 58 subjects, with >14 teeth of moderate-severe alveolar bone loss, and 2) Light-moderate group, 33 subjects; (4) To collect serum sample of patients and determine the IgG antibody titers to Pg in serum with ELISA. Results: (1) The mean IgG antibody titers to Pg in AgP group ( 8.55) were much higher than that in control group (4.78); (2) No significant difference ( 8.38 and 8.67, respectively) of mean IgG titers to Pg was found between male and female; (3) The mean of IgG titers to Pg ( 9.26) in elder group (aged >25) was significantly higher than that in younger patients (6.96); (4) Smokers had lower mean IgG titers to Pg (7.33) than non-smokers (8.78); (5) The mean IgG titers to Pg in severe AgP group was significantly higher than that in light-moderate AgP group. The results of multi-factor regression analysis showed that smoking, age and status of alveolar bone loss were the factors of affecting on IgG titers of antibody to Pg. Conclusions: The titers of IgG antibody to Pg in serum were related to age, smoking and periodontal status in AgP patients.