Relationship between volumes of gingival crevicular fluid and periodontal inflammation

Objectives: Gingival crevicular fluid (GCF) was the inflammatory exudation from serum. The aim of this investigation was to evaluate the relationship between the volumes of gingival crevicular fluid and periodontal inflammation.Methods: Clinical examinations including probing depth (PD), attachment level (AL), and gingivitis index (GI) were examined for total 165 periodontal sites from patients with periodontitis. Sulfur levels (SUL) were measured at the same sites using a Diamond Probe/Perio 2000 system. Gingival crevicular fluids were collected from these sites by filter paper strips, and the volumes of GCF were measured. According to the PD score £3mm, 4mm- 6mm, or ³7mm, all sites were divided into 3 groups respectively( L group, M group and H group). Volume of GCF in the three groups and the correlation between periodontal parameters and GCF volume were analyzed by statistical software SPSS. Results: The H group had statistically higher GCF volumes (2.16±0.67mg)than M group(1.15±0.45mg), and M group had statistically higher GCF volumes than L group (0.47±0.28mg)(P<0.01). In the L and M groups, Significantly positive correlations were observed between the volume of GCF and periodontal parameters including PD, AL, GI and SUL. In H group, the volumes of GCF positively correlate with AL and SUL. Conclusions: The volumes of GCF rise with the severity of the periodontal inflammation and destruction. Analyzing the GCF sample for some constituents (such as inflammatory mediator, cytokines) would contribute to the diagnose, monitoring and therapy of periodontal diseases.