Relationship between FcgR IIIb polymorphism and the susceptibility of periodontitis

Objectives: The purpose of the present study was to compare FcgR IIIb genotype of aggressive periodontitis (AgP) with chronic periodontitis (CP) and control group (Cont) in the Han nationality of China. Methods: We choosed 23 patients with aggressive periodontitis, 20 patients with chronic periodontitis according to established clinical criteria, and 22 matched healthy controls. Peripheral blood samples were taken from all patients and controls, then DNA was isolated from blood using DNA purification kit. Following, FcgR IIIb genotyping was determined by PCR and DNA sequencing. Results: FcgR IIIb NA1ANA2 frequencies didn't equal 1.00 in all 3 groups, and also without -SHA-NANULL genotype. So many new allele of -NA1 and -NA2 were found in all groups. However, there were no rules of new alleles in every group and between the groups, no statistic significance as well as. The -NA1 of FcgR IIIb Frequency was 0.77 ,and that of -NA2 was 0.23 in this study. With DNA sequencing, including mutation in these 5 nucleotides (141,147,227,277,349), there were other mutation sites in the 3rd exon of FcgR IIIb. uniformly, there were no statistic significance at all. Conclusions: Including FcgR IIIb NA1 and NA2, five alternate allele of -NA1 (NA1*01bANA1*02aANA1*02bANA1*03a and NA1*03b) and three alternate allele of -NA2(NA2*02ANA2*03 and NA2*04)were described. the results suggest that FcgR IIIb may not be a risk indicator for the susceptibility of periodontitis in the Han nationality of China.