Animal experiment of closing circular skin defects with purse-string Closure

Objectives: To testify the feasibility and advantages of the Purse-String Closure and second-stage lenticular excision/linear closure in closing the defects in maxillofacial skin, and to direct professionals to minimize the scar of skin. Methods:28 SD rats were divided into three groups (A,B and C) randomly. In A group, genas were excised a circular skin graft with diameter of 0.5cm. On 28th day after operation, a second-stage procedure: lenticular excision was carried out and the length of final scars were measured. In B group, each gena was underwent lenticular excision/linear closure, and the scars length was measured after 14 days. In group C, every gena was excised a circular skin graft too,and was remained undisturbed. Results: In group A, the mean scar area was only 11 percent of the original area after 28 days, and mean length of the final lineal scar was 0.516±0.052cm. In group B, the mean length was 1.341±0.122cm. In group C, the mean long-axial diameter (length) was 0.399cm, the mean short-axial diameter (width) was 0.353cm, the average width/length was 0.89:1, and the mean scar area was only 11 percent of the original area.It was statistically different between each group(p<0.01). Conclusion:The Purse-String Closure and second-stage lenticular excision/linear closure was a better method in closing circular skin defect.