Role of mTOR signaling in oral acinic cell carcinoma

Objectives: This study was aimed to observe the expression of P70 S6 kinase (P70 S6K) signal pathway in oral acinic cell carcinoma. Methods: P70 S6 kinase were examined by means of Western blot test and activity assay. Speciments from 30 cases of oral acinic cell carcinoma and 15 cases of normal oral tissue were used as control. Statistical analysis SPSS10.0 software was used for t test. t test were used to determine the relationship between gene expression and clinical features. Results: The expression level of the Western blot of p70 S6k increase obviously in oral acinic cell carcinoma tissue (P<0.01). Activity assay was same as the Western blot test (P<0.01). P70 S6K expression and activity played an important role in the development of oral acinic cell carcinoma. Conclusions: P70 S6K is amplified and overexpressed in oral acinic cell carcinoma tissue, which suggests a potential oncogenic function. p70 S6K and possibly other targets of mTOR contribute significantly to tumor development and that inhibition of these proteins may be therapeutic for cancer patients. Overexpression of P70 S6K may be involved in the pathogenesis of oral acinic cell carcinoma.