Expression of Runx2/Cbfa1 in the Developing Periodontal Tissues of Mice

Objective:To study the expression and function of Runx2/Cbfa1 in the developing periodontal tissues of mice. Methods:A mice developing periodontal tissue study model was created histologically, then the immunohistochemical localization of Runx2/Cbfa1 in different developing stages was undertaken. Results:The mice developing periodontal tissue model was successfully employed in the study. The span of the developing periodontal tissue was from 5th day to 27th day after the birth. Runx2/Cbfa1 was located merely in the developing alveolar bone matrix immunohistochemically in the initial stage during the root development; meanwhile, it was mainly in periodontal ligament cells, cementoblasts, osteoblasts and osteocytes except the alveolar bone matrix in the later stage. Conclusion:Runx2/Cbfa1 is an essential regular factor in the differentiation of cementoblasts and osteoblasts and in the formation of periodontal tissues. Supported by National Natural Scientific Foundation of China.30371537 and Shandong Provincial Excellent Young Scientist Scientific Foundation.02BS096.