Antitumor Study of Electrothermal & Electrochemical Therapy to Sarcoma180

Objective: Current methods used to treat cancer include hyperthermia and electrochemical therapy (ECT). Due to their individual disadvantages, the extent of treatment using these methods is limited. "Electrothermal and electrochemical therapy (ETECT)", a new treatment for cancer that combines both hyperthermia and ECT, is presently being evaluated for its antitumor effects and compared separately to hyperthermia and electrochemistry. The electrothermal & electrochemical device (ETECD) is used to carry out the experiment. Methods: A group of mice with Sarcoma180 (1cm in diameter) were divided randomly into four groups and given different treatments: Control, ECT alone, ETT alone and ETECT. The volumes of the tumors were calculated everyday after the treatment was performed. The tumor examined were morphologically at 0, 6, 24 and 72 hours after treatment. Results: The tumors in the group of mice that were treated with ETECT were completely destroyed, and did not recur within a period of ten days upon pathological examination. Results of this group were significantly different with the other groups (p<0.01). However,recurred tumors were found in 6 mice of ETT group and 5 mice of ECT group, respectively. Conclusion: Based on the results obtained, ETECT induced by ETECD is an effective way to eliminate cancer. It is capable of completely destroying cancer cells in a short amount of time such that the rate of Sarcoma180 inhibition is up to 100%, and malignant cells can't recur. The research provided theoretical and experimental bases for the treatment of oral cancer and the development of a new approach to treat cancer.