IADR Abstract Archives
Anticaries properties of natural berries: Systematic literature review
Objectives: Present in high concentrations in numerous fruits, anticariogenic properties have been described for polyphenol compounds. Berries have been reported as potentially having an inhibitory effect on the dental biofilm and subsequently on caries, but the evidence is unclear. The aim oof this research was to explore the literature to summarize the evidence on the potential anticaries effect of berries and on their inhibitory effect on the dental biofilm.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, PubMed, Web of Science, and SCOPUS databases were scanned using predefined and accessible terms, with a search strategy based on a structured PICO question. After article selection, 23 studies met the inclusion criteria, most of them in vitro. Data from those studies were extracted in a table for qualitative analysis. Meta-analyses were conducted using standardized mean differences with a 95% confidence interval by Review manager 5.4.
Results: Only 3 types of berries were found to have a reported anticaries effect; grape seed extract (GSE), cranberry, and sour cherry. In general, these berries would have a potential as anticaries agents. Nine studies that fulfilled the eligibility criteria were subjected to quantitative analysis. Meta-analyses showed GSE was associated with enhanced remineralization (SMD=0.96 CI95% [0.45,1.46], p<0.0002) on dental enamel and (SMD=0.65 CI95% [0.13,1.17], p=0.01) on dentin. Cranberry extracts positively influence the cariogenic dental biofilm by decreasing biomass (SMD=-2.23 CI95% [-4.40,-0.05], P=0.04), and biovolume (SMD=-2.86 CI 95% [-4.34,-1.37], p=0.0002), and increasing biofilm pH (SMD= 7.9 CI95% [3.49,12.31], p<0.0004).
Conclusions: Within the limitations of this systematic review and meta-analysis, GSE and cranberries or their active compounds could represent an alternative for caries management. Further clinical trials are needed to verify this effect in a clinical situation.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, PubMed, Web of Science, and SCOPUS databases were scanned using predefined and accessible terms, with a search strategy based on a structured PICO question. After article selection, 23 studies met the inclusion criteria, most of them in vitro. Data from those studies were extracted in a table for qualitative analysis. Meta-analyses were conducted using standardized mean differences with a 95% confidence interval by Review manager 5.4.
Results: Only 3 types of berries were found to have a reported anticaries effect; grape seed extract (GSE), cranberry, and sour cherry. In general, these berries would have a potential as anticaries agents. Nine studies that fulfilled the eligibility criteria were subjected to quantitative analysis. Meta-analyses showed GSE was associated with enhanced remineralization (SMD=0.96 CI95% [0.45,1.46], p<0.0002) on dental enamel and (SMD=0.65 CI95% [0.13,1.17], p=0.01) on dentin. Cranberry extracts positively influence the cariogenic dental biofilm by decreasing biomass (SMD=-2.23 CI95% [-4.40,-0.05], P=0.04), and biovolume (SMD=-2.86 CI 95% [-4.34,-1.37], p=0.0002), and increasing biofilm pH (SMD= 7.9 CI95% [3.49,12.31], p<0.0004).
Conclusions: Within the limitations of this systematic review and meta-analysis, GSE and cranberries or their active compounds could represent an alternative for caries management. Further clinical trials are needed to verify this effect in a clinical situation.