IADR Abstract Archives
Autologous Platelet Concentrates Efficacy in Regenerative Endodontics: Systematic Review
Objectives: To analyze the quality of the evidence from studies that compare the clinical efficacy of blood clot (BC) versus Autologous Platelet Concentrates (APCs) in non-vital immature teeth treated with regenerative endodontics (RE).
Methods: Randomized Clinical Trials (RCTs) comparing CPAs with BC in patients with non-vital immature teeth treated with ER were included. A systematic electronic search was performed in MEDLINE, THE COCRHANE LIBRARY, EMBASE, ScienceDirect, Scielo, LILACS, OpenGrey, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform. A hand search was also performed in journals and conferences minutes or abstracts related to endodontics. The search included all publications without a year or language limit. Quality of the evidence was assessment through the “Risk of Bias 2” Cochrane tool.
Results: Seven articles corresponding to RCTs were included for analysis (Figure 1). Four out of seven studies reported better CPA performance over CS. One low risk of bias study reports statistically better results of PRP in apical healing, apical closure, lengthening and root thickening. Two “some concerns” risk of bias studies, reports a better performance of PRP, one in apical healing and the other in lengthening root. One high risk of bias study inform significantly greater apical healing, lengthening and root thickening of PRF over CS.
Conclusions: Included studies have a moderate to low quality of evidence, therefore RCTs with protocols and standardized outcome measures are needed, along with longer follow-up times.
Methods: Randomized Clinical Trials (RCTs) comparing CPAs with BC in patients with non-vital immature teeth treated with ER were included. A systematic electronic search was performed in MEDLINE, THE COCRHANE LIBRARY, EMBASE, ScienceDirect, Scielo, LILACS, OpenGrey, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform. A hand search was also performed in journals and conferences minutes or abstracts related to endodontics. The search included all publications without a year or language limit. Quality of the evidence was assessment through the “Risk of Bias 2” Cochrane tool.
Results: Seven articles corresponding to RCTs were included for analysis (Figure 1). Four out of seven studies reported better CPA performance over CS. One low risk of bias study reports statistically better results of PRP in apical healing, apical closure, lengthening and root thickening. Two “some concerns” risk of bias studies, reports a better performance of PRP, one in apical healing and the other in lengthening root. One high risk of bias study inform significantly greater apical healing, lengthening and root thickening of PRF over CS.
Conclusions: Included studies have a moderate to low quality of evidence, therefore RCTs with protocols and standardized outcome measures are needed, along with longer follow-up times.
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