IADR Abstract Archives
The evaluation of buccal drug delivery route for analgesics using microneedle array geometries compared by finite element method.
Objectives: The transdermal drug delivery systems, microneedles (MN), have played an important role in recent medical and pharmaceutical applications, presenting themselves as a painless, efficient, and easy-to-apply alternative in the administration of drugs. This MN consists of matrix systems of needles on a micro-scale, which are lodged in the dermis or epidermis. The present work evaluated four different geometries presentations of MNs for buccal local anesthetics delivery.
Methods: The MNs were compared to hollow MNs, keeping all the required mechanical parameters for height (600 µm), basal diameter (300 µm), and dose release for each channel (90 µm). The analysis was validated through numerical simulations through finite elements methods (FEM), both the total deformations, Von Mises stresses, and dynamics of fluids (CFD) using ANSYS software (ANSYS 2021 R1, Maule, Chile).
Results: The strengths simulated range force application of 2mN to 30mN. The behavior of local drug delivery of anesthetic agents was established for MNs systems, and efforts were considered for the multilayer system of the buccal mucosa. Within the simulations, a maximum deformation of 43 µm and the stresses of 70 MPa were found.
Conclusions:
This new MN consists of a matrix system of needles with acceptable mechanical valuables as a new and improved drug delivery method in dentistry.
Methods: The MNs were compared to hollow MNs, keeping all the required mechanical parameters for height (600 µm), basal diameter (300 µm), and dose release for each channel (90 µm). The analysis was validated through numerical simulations through finite elements methods (FEM), both the total deformations, Von Mises stresses, and dynamics of fluids (CFD) using ANSYS software (ANSYS 2021 R1, Maule, Chile).
Results: The strengths simulated range force application of 2mN to 30mN. The behavior of local drug delivery of anesthetic agents was established for MNs systems, and efforts were considered for the multilayer system of the buccal mucosa. Within the simulations, a maximum deformation of 43 µm and the stresses of 70 MPa were found.
Conclusions:
This new MN consists of a matrix system of needles with acceptable mechanical valuables as a new and improved drug delivery method in dentistry.