IADR Abstract Archives
Cardiovascular Risk And Endodontic Treatment In Adults With Apical Periodontitis
Objectives: To determine whether root canal treatment can reduce cardiovascular risk (CVR) based on serum hsCRP and lipid profile in individuals with apical periodontitis during 12 months follow-up.
Methods: Quasi-experimental study, 22 otherwise healthy young adults between 18 and 40 years old with apical lesions of endodontic origin (ALEOs) were included. Exclusion criteria were periodontal diseases, obesity, anti-inflammatory/antibiotic treatment in the previous 3m and pregnancy. Patient’s medical history, sociodemographic characteristics and classic cardiovascular risk factors were recorded. Oral clinical-radiographic examinations and blood samples to determine hsCRP and lipid profile at University Hospital clinical laboratory were performed at baseline (BL) and after root canal treatment at 1, 6 and 12 months. Data were analyzed with Wilcoxon or T-Student paired test.
Results: Twenty one patients between 18 and 40 years old, 76.19% female and 23.81% male, smokers (42.86%), most patients had one apical lesion (90.5%) and 47.6% showed an altered lipid profile with no medical diagnosis of dyslipidemia. HsCRP levels at baseline and up to 12 months were within moderate CVR level (median 1.1 and 1.4 mg/L, respectively; Total cholesterol and low density lipoprotein significantly increased during the follow up period (Mean diff. -17 and -16.5 mg/dL, respectively; p<0.05) whereas high density lipoprotein and triglycerides showed no change (Mean diff. +0.125 mg/dL and -3.5 mg/dL, p>0.05).
Conclusions: CVR remained moderate based on serum hsCRP risk stratification during 12 months follow-up after endodontic treatment in young adults. Lipid profile showed increasing of total cholesterol and LDL, but remained within normal range.
Methods: Quasi-experimental study, 22 otherwise healthy young adults between 18 and 40 years old with apical lesions of endodontic origin (ALEOs) were included. Exclusion criteria were periodontal diseases, obesity, anti-inflammatory/antibiotic treatment in the previous 3m and pregnancy. Patient’s medical history, sociodemographic characteristics and classic cardiovascular risk factors were recorded. Oral clinical-radiographic examinations and blood samples to determine hsCRP and lipid profile at University Hospital clinical laboratory were performed at baseline (BL) and after root canal treatment at 1, 6 and 12 months. Data were analyzed with Wilcoxon or T-Student paired test.
Results: Twenty one patients between 18 and 40 years old, 76.19% female and 23.81% male, smokers (42.86%), most patients had one apical lesion (90.5%) and 47.6% showed an altered lipid profile with no medical diagnosis of dyslipidemia. HsCRP levels at baseline and up to 12 months were within moderate CVR level (median 1.1 and 1.4 mg/L, respectively; Total cholesterol and low density lipoprotein significantly increased during the follow up period (Mean diff. -17 and -16.5 mg/dL, respectively; p<0.05) whereas high density lipoprotein and triglycerides showed no change (Mean diff. +0.125 mg/dL and -3.5 mg/dL, p>0.05).
Conclusions: CVR remained moderate based on serum hsCRP risk stratification during 12 months follow-up after endodontic treatment in young adults. Lipid profile showed increasing of total cholesterol and LDL, but remained within normal range.