IADR Abstract Archives
Effects of Omega 3 on Sleep: Systematic Review.
Objectives: To determine the effect of omega-3 on the quality and/or quantity of sleep in humans.
Methods: A systematic search of articles published between the years 2010-2019, in six databases, was carried out. Patients without age or sex limitation, who had undergone diet changes or omega-3 supplementation were included. An evaluation of sleep quality/quantity was performed. The systematic review was conducted under the PICOT eligibility and collection criteria, the PRISMA criteria for systematic reviews were applied and the quality of evidence and bias were assessed according to GRADE criteria.
Results: Six randomized clinical trials passed all filters, totaling 1013 patients (230 adults and 783 children). Two studies modified the diet by including fish three times a week and in four studies patient’s ingested different amounts of omega-3. Omega-3 favorably impacts sleep in four studies, three in adults and one in children, while two studies showed no significant effect. Omega-3 improves moderately the quality of sleep and presents high positive impact in quantity of sleep. The studies were carried out with highly heterogeneous variables, making impossible a quantitative analysis of the data, due to the implementation of various type of questionnaires and especially because objective measurements of comparable biomarkers were not available in all studies. The level of bias was moderate to high.
Conclusions: A promising trend was observed in the use of omega-3 as an adjuvant to improve the quantity and quality of sleep, as a supplement or directly in food. The studies presented great heterogeneity both in the methodologies to measure the intervention, in the populations studied and in the form of omega-3 intake, making it impossible to conclude recommendations for clinical use. Studies with greater methodological standardization are needed to determine optimal dose, intervention period and EPA/DHA ratio required to improve the quality and quantity of sleep.
Methods: A systematic search of articles published between the years 2010-2019, in six databases, was carried out. Patients without age or sex limitation, who had undergone diet changes or omega-3 supplementation were included. An evaluation of sleep quality/quantity was performed. The systematic review was conducted under the PICOT eligibility and collection criteria, the PRISMA criteria for systematic reviews were applied and the quality of evidence and bias were assessed according to GRADE criteria.
Results: Six randomized clinical trials passed all filters, totaling 1013 patients (230 adults and 783 children). Two studies modified the diet by including fish three times a week and in four studies patient’s ingested different amounts of omega-3. Omega-3 favorably impacts sleep in four studies, three in adults and one in children, while two studies showed no significant effect. Omega-3 improves moderately the quality of sleep and presents high positive impact in quantity of sleep. The studies were carried out with highly heterogeneous variables, making impossible a quantitative analysis of the data, due to the implementation of various type of questionnaires and especially because objective measurements of comparable biomarkers were not available in all studies. The level of bias was moderate to high.
Conclusions: A promising trend was observed in the use of omega-3 as an adjuvant to improve the quantity and quality of sleep, as a supplement or directly in food. The studies presented great heterogeneity both in the methodologies to measure the intervention, in the populations studied and in the form of omega-3 intake, making it impossible to conclude recommendations for clinical use. Studies with greater methodological standardization are needed to determine optimal dose, intervention period and EPA/DHA ratio required to improve the quality and quantity of sleep.