IADR Abstract Archives
C-Reactive Protein And Cardiovascular Risk In Women With Periodontal Diseases
Objectives: To assess the association between periodontal diseases (gingivitis and periodontitis) and cardiovascular risk (CVR), measured by serum high sensitivity C-reactive protein (hs-CRP); and secondarily, to determine the correlation between serum and gingival crevicular fluid (GCF) CRP concentration in Chilean adult women.
Methods: Quantitative, analytical and cross-sectional study performed at the Faculty of Dentistry, University of Chile, between 2017 and 2020. One hundred and twelve otherwise healthy Chilean women, between 18 and 44 years old, underwent periodontal clinical examination and were classified into three groups: healthy (n=37), gingivitis (n=39) and periodontitis (n=36). Age, educational level, smoking, body mass index, blood pressure, glycosylated hemoglobin and lipid profile were recorded or either obtained from blood samples. CRP levels in serum and GCF were analyzed by turbidimetric method and Luminex technology, respectively. Cardiovascular risk was adjusted by classic CVR factors. Data were analyzed using STATA®12.0 software (p<0.05).
Results: Periodontitis and gingivitis women did not differ significantly regarding serum hs-CRP levels (1.7 [2.9] mg/L and 1.3 [2] mg/L, respectively) from the healthy ones (1.3 [3.3] mg/L) (p>0.05). There was no significant association between periodontal status and cardiovascular risk, with a moderate CVR in all groups (p>0.05). Women with periodontal disease (gingivitis and periodontitis) had significantly higher concentrations of CRP in GCF (1178.2x10e-6 [2882.5x10e-6] and 1131.3x10e-6 [3667.6x10e-6] mg/L, respectively) than healthy women (157x10e-6 [398.1x10e-6] mg/L) (p<0.001), and there was a statistically significant association between serum and GCF CRP levels in all groups (p=0.00).
Conclusions: All women presented moderate CVR, with no evident association between serum hs-CRP levels and periodontal disease status. Gingivitis and periodontitis participants had significantly higher CRP levels in GCF, which correlated significantly with serum CRP levels.
Methods: Quantitative, analytical and cross-sectional study performed at the Faculty of Dentistry, University of Chile, between 2017 and 2020. One hundred and twelve otherwise healthy Chilean women, between 18 and 44 years old, underwent periodontal clinical examination and were classified into three groups: healthy (n=37), gingivitis (n=39) and periodontitis (n=36). Age, educational level, smoking, body mass index, blood pressure, glycosylated hemoglobin and lipid profile were recorded or either obtained from blood samples. CRP levels in serum and GCF were analyzed by turbidimetric method and Luminex technology, respectively. Cardiovascular risk was adjusted by classic CVR factors. Data were analyzed using STATA®12.0 software (p<0.05).
Results: Periodontitis and gingivitis women did not differ significantly regarding serum hs-CRP levels (1.7 [2.9] mg/L and 1.3 [2] mg/L, respectively) from the healthy ones (1.3 [3.3] mg/L) (p>0.05). There was no significant association between periodontal status and cardiovascular risk, with a moderate CVR in all groups (p>0.05). Women with periodontal disease (gingivitis and periodontitis) had significantly higher concentrations of CRP in GCF (1178.2x10e-6 [2882.5x10e-6] and 1131.3x10e-6 [3667.6x10e-6] mg/L, respectively) than healthy women (157x10e-6 [398.1x10e-6] mg/L) (p<0.001), and there was a statistically significant association between serum and GCF CRP levels in all groups (p=0.00).
Conclusions: All women presented moderate CVR, with no evident association between serum hs-CRP levels and periodontal disease status. Gingivitis and periodontitis participants had significantly higher CRP levels in GCF, which correlated significantly with serum CRP levels.