IADR Abstract Archives

Periodontitis and Alzheimer’s Disease Biomarkers, Common Pathways in Down Syndrome

Objectives: The aim of this study was to determine the presence of molecular and microbiological biomarkers associated with periodontitis and Alzheimer’s Disease (AD) in individuals with Down Syndrome (DS)
Methods: Patients with DS (cases) and without DS (controls) were studied. Periodontal screening and recording were determined for each individual. Subgingival microbiota and gingival crevicular fluid samples were taken to quantify the presence of P. gingivalis, and cytokine profiles, and ApoE-ε4.
Results: A correlation between P. gingivalis and early stages of periodontal disease was established in the DS population, especially related to probing depth . Cytokine analysis revealed no differences amongst DS individuals and their periodontal status, except IL-1β, a pro-inflammatory cytokine, relevant in both AD and periodontitis. ApoE-ε4 —a known risk factor for AD— in DS individuals was found to be in a higher concentration in individuals with stage III and IV periodontitis.
Conclusions: This is the first clinical study to inquire about the relationship between AD and PD biomarkers in DS individuals. Associations between periodontal stages, bacterial load, and ApoE-ε4 were established. Bidirectional relationships (AD-DS, DS-periodontitis, periodontitis-AD) have been studied and discussed, but the current study brings to light the need to further study the pathways that exist amongst the three conditions.

2020 Chilean Division Meeting (Virtual)

2020

Periodontal Research-Pathogenesis
  • Arriola, Fabio  ( Faculty of Dentistry, Yucatán, MX , Merida , Yucatán , Mexico )
  • Díaz-zuñiga, Jaime  ( Universidad de Chile, Universidad de Chile, Santiago de Chile, CL , Santiago de Chile , Chile )
  • Pinzón-te, Alicia Leonor  ( Faculty of Dentistry, Yucatán, MX , Merida , Yucatán , Mexico )
  • Martinez-aguilar, Victor Manuel  ( Universidad Autonoma de Yucatan, Faculty of Dentistry, Merida, Yucatán, MX , Merida , Yucatán , Mexico )
  • NONE
    Experimental periodontal infection induced by Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans and its association with Alzheimer’s disease. Looking for the potential risk factor”, by Regional Development Program de la IADR.
    Oral Session
    Oral Session 4