IADR Abstract Archives
C-Reactive Protein From Gingival Crevicular Fluid: Cardiovascular Risk In Periodontitis
Objectives: To associate the levels of C reactive protein (CRP) in gingival crevicular fluid (GCF) with the periodontal state and cardiovascular risk in adult chilean women under 45 years of age.
Methods: Quantitative, analytical and cross-sectional study. Forty chilean women who attended the dental clinic of the Faculty of Dentistry, University of Chile, were included between years 2017 and 2018. Volunteers between 18 and 44 years old who presented periodontal health (n = 23) and periodontitis (n = 17) participated in the study. Clinical history and periodontal clinical parameters were registered. Body mass index, blood pressure, glycosylated hemoglobin, lipid profile and serum CRP levels were recorded. GCF samples were obtained to determine CRP levels, which were associated with the periodontal status and cardiovascular risk level. The statistical analysis was carried out with the STATA®12.0 program (p <0.05).
Results: CRP levels from GCF of periodontitis women were statistically higher than CRP levels from GCF of healthy women (p=0.00). In addition, a significant association was observed between high levels of CRP in GCF, and having periodontitis (p=0.03, CI:1.19-36.31). Patients with crevicular fluid CRP levels ≥ 3 mg / L were 6.48 times more likely to have a high cardiovascular risk (p=0.04, CI:1.05-39.66), according to serum CRP levels and adjusted to classic cardiovascular risk factors.
Conclusions: Adult Chilean women under 45 years old who presented periodontitis had higher levels of CRP in GCF, in comparison to healthy controls. There is a significant association between high levels of CRP in the GCF and high cardiovascular risk.
Methods: Quantitative, analytical and cross-sectional study. Forty chilean women who attended the dental clinic of the Faculty of Dentistry, University of Chile, were included between years 2017 and 2018. Volunteers between 18 and 44 years old who presented periodontal health (n = 23) and periodontitis (n = 17) participated in the study. Clinical history and periodontal clinical parameters were registered. Body mass index, blood pressure, glycosylated hemoglobin, lipid profile and serum CRP levels were recorded. GCF samples were obtained to determine CRP levels, which were associated with the periodontal status and cardiovascular risk level. The statistical analysis was carried out with the STATA®12.0 program (p <0.05).
Results: CRP levels from GCF of periodontitis women were statistically higher than CRP levels from GCF of healthy women (p=0.00). In addition, a significant association was observed between high levels of CRP in GCF, and having periodontitis (p=0.03, CI:1.19-36.31). Patients with crevicular fluid CRP levels ≥ 3 mg / L were 6.48 times more likely to have a high cardiovascular risk (p=0.04, CI:1.05-39.66), according to serum CRP levels and adjusted to classic cardiovascular risk factors.
Conclusions: Adult Chilean women under 45 years old who presented periodontitis had higher levels of CRP in GCF, in comparison to healthy controls. There is a significant association between high levels of CRP in the GCF and high cardiovascular risk.