IADR Abstract Archives
Does Chronic Periodontitis modify the Rheumatoid Arthritis’s morbidity ? Clinical and molecular aspects.
Objectives: The aim was to determine if Chronic Periodontitis (CP) modifies the Rheumatoid Arthritis (RA) morbidity, analyzing clinical and molecular aspects.
Methods: The Pubmed database was searched by two independent researchers, using "periodontitis" and "rheumatoid arthritis" as keywords and "AND" as Boolean term. Five hundred and fifty- two articles were found in the initial search.
Then, the inclusion criteria were applied: observational and clinical studies of the last 10 years, in humans and published in english. Titles and abstracts were evaluated applying inclusion criteria and the duplicates articles were deleted. Forty-three articles were obtained and finally sixteen were selected by analizing full text.
Results: A higher prevalence of CP was observed in RA patients in comparison to healthy controls, RA patients with CP have higher DAS28 scores, count of sensitive joints and greater radiographic damage than patients without CP. Furthermore, non-surgical periodontal treatment reduce RA activity and also the periodontal clinical parameters's values are higher in RA compared to healthy controls. In the molecular aspects, the antibody response against P. Gingivalis increases in patients with RA compared to healthy controls. It has been observed in CP patients, that antibodies against PPAD are elevated in RA compared to non-RA group. In relation to RA disease markers, higher values of Erythrocyte Sedimentation Rate (ESR), C- Reactive Protein (CRP), Rheumatoid Factor (RF) and antibody against Cyclic Citrullinated Peptide (CCP) were found in CP patients than controls without CP
Conclusions: Current evidence suggests an association between CP and RA, however more extensive and larger cohort studies would be necessary to better assess the common pathologic features and to define the complex etiopathogenic mechanism that would be involved
Methods: The Pubmed database was searched by two independent researchers, using "periodontitis" and "rheumatoid arthritis" as keywords and "AND" as Boolean term. Five hundred and fifty- two articles were found in the initial search.
Then, the inclusion criteria were applied: observational and clinical studies of the last 10 years, in humans and published in english. Titles and abstracts were evaluated applying inclusion criteria and the duplicates articles were deleted. Forty-three articles were obtained and finally sixteen were selected by analizing full text.
Results: A higher prevalence of CP was observed in RA patients in comparison to healthy controls, RA patients with CP have higher DAS28 scores, count of sensitive joints and greater radiographic damage than patients without CP. Furthermore, non-surgical periodontal treatment reduce RA activity and also the periodontal clinical parameters's values are higher in RA compared to healthy controls. In the molecular aspects, the antibody response against P. Gingivalis increases in patients with RA compared to healthy controls. It has been observed in CP patients, that antibodies against PPAD are elevated in RA compared to non-RA group. In relation to RA disease markers, higher values of Erythrocyte Sedimentation Rate (ESR), C- Reactive Protein (CRP), Rheumatoid Factor (RF) and antibody against Cyclic Citrullinated Peptide (CCP) were found in CP patients than controls without CP
Conclusions: Current evidence suggests an association between CP and RA, however more extensive and larger cohort studies would be necessary to better assess the common pathologic features and to define the complex etiopathogenic mechanism that would be involved