IADR Abstract Archives
Soluble Neuropilin-1 In Pregnant Women's Gingival Crevicular Fluid With Periodontitis
Objectives: To assess the presence of soluble Neuropilin-1 (sNRP-1) in gingival crevicular fluid (GCF) of early pregnancy women with distinct severities of periodontitis and its relationship with different periodontal parameters.
Methods: A case-control study was performed. GCF samples were collected from 80 early pregnancy women (11–14 weeks of gestation) with different severities of periodontitis belonging to the Karol Wojtyla health service located in Puente Alto (Santiago, Chile). Quantification of sNRP-1 in GCG was determined by ELISA assay. Full-mouth clinical periodontal parameters such as bleeding on probing (BOP) and periodontal inflamed surface area (PISA) were also recorded. Data was analyzed using descriptive statistics and the relationship between the number of patients sNRP-1 (+) with periodontitis severity and periodontal parameters was determined by Kruskal-Wallis and Mann-Whitney tests, respectively. Finally, the correlation between sNRP-1 levels and periodontal parameters was estimated through Spearman test.
Results: A greater amount of sNRP-1 was observed in GCF from pregnant women with severe (41.67%) and moderate (41.17%) periodontitis compared with those with mild periodontitis (18.8%). sNRP-1 (+) pregnant women had increased BOP (76,5% v/s 57%; p=0.0071) and PISA (1199,5 mm2 v/s 880,2 mm2; P = 0.0282) compared with sNRP-1 (-) pregnant women. However, no difference was observed in probing deep and clinical attachment loss. A positive correlation of 0.29 (p=0.0081) and 0.23 (p=0.0398) was observed between sNRP-1 levels with BOP and PISA, respectively.
Conclusions: The present findings suggest that sNRP-1 may have a role in the pathogenesis of periodontitis during pregnancy favoring the inflammatory and angiogenic processes that can be exacerbated during this period.
Methods: A case-control study was performed. GCF samples were collected from 80 early pregnancy women (11–14 weeks of gestation) with different severities of periodontitis belonging to the Karol Wojtyla health service located in Puente Alto (Santiago, Chile). Quantification of sNRP-1 in GCG was determined by ELISA assay. Full-mouth clinical periodontal parameters such as bleeding on probing (BOP) and periodontal inflamed surface area (PISA) were also recorded. Data was analyzed using descriptive statistics and the relationship between the number of patients sNRP-1 (+) with periodontitis severity and periodontal parameters was determined by Kruskal-Wallis and Mann-Whitney tests, respectively. Finally, the correlation between sNRP-1 levels and periodontal parameters was estimated through Spearman test.
Results: A greater amount of sNRP-1 was observed in GCF from pregnant women with severe (41.67%) and moderate (41.17%) periodontitis compared with those with mild periodontitis (18.8%). sNRP-1 (+) pregnant women had increased BOP (76,5% v/s 57%; p=0.0071) and PISA (1199,5 mm2 v/s 880,2 mm2; P = 0.0282) compared with sNRP-1 (-) pregnant women. However, no difference was observed in probing deep and clinical attachment loss. A positive correlation of 0.29 (p=0.0081) and 0.23 (p=0.0398) was observed between sNRP-1 levels with BOP and PISA, respectively.
Conclusions: The present findings suggest that sNRP-1 may have a role in the pathogenesis of periodontitis during pregnancy favoring the inflammatory and angiogenic processes that can be exacerbated during this period.