Objectives: The objective of this study was to know the implications involved in the use of health students as research subjects (RS) an investigation. Methods: A review of the literature was made in the databases PUBMED, EMBASE, SCOPUS, EBSCOhost and SciELO, without limits of years and with eligibility criteria. Results: We found 215 articles in the five databases consulted and 35 were selected after a review by title and abstract for a complete reading. After applying the inclusion criteria, 21 articles contributed information in relation to the considerations that should be known when using students as RS. Of the selected articles thirteen are narrative reviews, three letters to the editor, three survey applications, one study of creation and validation of a survey and one qualitative study. Three themes were the ones most represented by the authors: Scientific ethics when involving students as RS in research; benefits that your participation brings as RS; responsibility of review institutions or scientific ethical committees. Conclusions: The participation of students as RS an investigation can become an academically enriching instance, but there is little evidence that reports the true student benefits of participation. The use of students as study subjects has increased over the years, requiring researchers to know the ethical implications involved in their participation. Recognizing the measures for their protection is important and the scientists call for an international unification of these criteria in order to solve the frequent discrepancies see when requesting the evaluation of this type of projects by different review institutions, which will also benefit the researchers and editors of scientific journals.