Oral Manifestations And Salivary Biomarkers In Patients With Cystic Fibrosis.

Objectives: To determine the oral manifestations and salivary biomarkers alterations resulting from cystic fibrosis or chronic consumption of drugs for the treatment of this disease.
Methods: In this case report, we worked with a sample size of nine people, five with cystic fibrosis and four people without the disease, belonging to the 8th Chilean Region, Concepción. Different clinical manifestations of the oral cavity were observed in subjects suffering from the disease. Salivary pH, buffer capacity, total protein concentration and stimulated salivary flow rate were also measured and salivary enzymes were determined in all subjects.
Results: It was found evidence that salivary pH in subjects with cystic fibrosis tends to be slightly more alkaline, salivary flow rate is much lower and the same for the buffer capacity, the total protein concentration in saliva is equal to the reference values and the presence of salivary enzymes by molecular weight range was determined by electrophoresis technique. With regard to manifestations in the oral cavity, several lesions are seen in both soft tissues and hard tissues.
Conclusions: Cystic fibrosis affects in general the full health of these patients, therefore the dentist as part of the multidisciplinary team must have sufficient knowledge of this disease and be able to perform a treatment with the appropriate approach according to more prevalent oral diseases than these patients present.