Effect of L-PRF on Stability of early loaded Immediate Implants

The present study was conducted to compare clinically and radiographically the effect of leukocytes and platelets-rich fibrin (L-PRF) on the stability and crestal bone resorption of immediately placed and early loaded implants.

Method:

Twenty implants (Screw-plant, Spectra system, USA) were placed in the maxillary anterior and premolar regions of 10 patients. In a split-mouth design, each patient received two implants, one implant was placed with L-PRF plug (test) and the other implant (control) was placed without L-PRF plug in fresh extraction sockets. Implants were early loaded (after 2 months). Implant stability was measured using Osstell device (Integration Diagnostics, Sweden) at 0, 2, 4 and 6 months after implant placement. Crestal bone resorption was measured utilizing standardized periapical radiographs (Digora software) 4 and 6 months after placement. Student’s t test was used for statistical analysis.

Results:

Results revealed a survival rate of 88.9% for implants before loading but none of the implants were lost after loading. There was no significant difference between the mean of Osstell ISQ (Implant Stability Quotient) values for both the test and control sides at the base line, two months and four months while at six months the control side showed statistically significant higher Osstell reading values compared to the test side (mean test:65.25, SD:±6.86 , mean control:73.38, SD: ±7.02 ;p= 0.0344).

There was a statistically significant increase in the mean percentage change of crestal bone resorption in the control side compared to the test side during the loading period (Mean% change test:1mm, SD:±0.21 , Mean% change control: 17.05mm, SD:±4.38 ;p = 0.0001).

Conclusion:

Implant stability wasn’t affected by local application of L-PRF as a plug over immediately placed dental implants. However, a decrease in the rate of the crestal bone resorption “through the first six months period” was noted in early loaded dental implants.