Fas, Fas Ligand, and IL-6 Polymorphisms in drug-induced gingival overgrowth

Decreased apoptosis play an important role in the pathogenesis of the  cyclosporine A (CsA) induced gingival overgrowth (GO). Apoptosis triggered by Fas-FasL binding is involved in the regulation of the immune system. The aim of this study was to evaluate the relationship between the Fas, Fas ligand (FasL), and interleukin-6 (IL-6) gene polymorphisms and susceptibility to CsA-induced GO.

Method:

Genomic DNA was obtained from the blood of 120 renal transplant patients receiving CsA therapy; 51 with gingival overgrowth (GO+) and 69 with no sign of gingival overgrowth (GO-), and 52 tacrolimus medicated renal transplant patients without GO (TAC) The Fas -670A/G, FasL -843C/T and IL-6 -174G/C gene polymorphisms were evaluated using the polymerase chain reaction-restriction fragment length polymorphism method. Periodontal status was evaluated by measuring probing depth, plaque index, papilla bleeding and hyperplastic index.

Result:

The evaluation of the Fas, FasL and IL-6 genotype and the gene allele frequency did not show statistically significant differences between the GO+ and GO- groups. Fas, FasL and IL-6 genotype and the gene allele frequency were also similar between GO+ and TAC groups.

Conclusion:

Our findings suggest that the Fas -670A/G, FasL -843C/T and IL-6 -174G/C gene polymorphisms are not associated with CsA induced GO in renal tansplant patients.