WSLs Remineralización With Tooth Pastes Containing Recaldent Technology

to evaluate the effects of casein phosphopeptide (CPP) formulations (CPP-amorphous calcium phosphate (CCP-ACP) and CPP-amorphous calcium fluoride phosphate (CPP-ACFP)) on the remineralization of enamel white spot lesions (WSLs) over a 12-week follow-up period.

Method:

a double-blinded prospective study was performed. Eligibility criteria: patients must be 6–14 years old and have WSLs on their permanent teeth. We recruited 60 eligible participants with a collective total of 786 WSLs from a primary dental care clinic in Valencia, Spain, between February and September, 2011. Participants were instructed to clean their teeth daily and were divided randomly into three groups. All patients were instructed to use twice a day a 1000 ppm fluoridated paste (Colgate). Groups A and B were instructed to topically apply GC Tooth Mouse (CPP-ACP) or Mi Paste Plus (CPP-ACFP) once daily, while Group C received a non-fluoridated paste applied once daily. WSLs were assessed using DIAGNOdent at baseline and at 4, 8 and 12 weeks after treatment initiation, to test the hypothesis that CPP formulations offer superior remineralization to control group. Changes in mineralization status before and after treatment were statistically analyzed using two-way analysis of variance, with post hocBonferroni’s non-parametric tests for multiple comparisons.

Result:

DIAGNOdent values of caries presence were significantly reduced in Group B from 4 weeks onwards, and in Groups A from 8 weeks onwards. Mean values in Group B were lower than in Groups A at 4 weeks.

Conclusion:

Remineralization in study groups (CPP-ACFP and CPP-ACP) was higher than in the control group in all evaluation points along the observation period.