Screening of Oral Cancer by Using Mass Spectrometry Method

Objectives: Cancer is the 2nd leading cause of death worldwide. The morbidity and mortality of oral cancer cause a heavy impact on quality of life, life expectancy and economy. A variety of commercial diagnostic procedures are available to potentially assist in the screening of non-cancer but high-risk patients. With the increasing population of cancer patients scientists worldwide are challenged to find new and better ways for prevention and early detection. Methods: Mass spectrometric profiling of the protein expression by pathological tissues is a non invasive saliva examination. This presentation focuses on the recent discoveries of new procedures of biomarkers detection for early cancer diagnose by means of MALDI-TOF mass spectrometry. Results: we found the previously detected peptides in all saliva samples of all oral cancer patients using by targeted peptide analysis. Conclusion: This high-throughput method could be a new promising possibility of screening of high risk people (early smokers, homelesses, etc).