Complex dental treatment effects on serum parameters of hyperlipidemic patients

Objectives: The aim of this study was to investigate the associations between the oral health indicators and serum inflammatory and lipid parameters and human paraoxonase-1 (PON1) activity in hyperlipidemic patients. Methods: Thirty four Caucasian patients (mean age 55.12±11.55) with hyperlipidemia and thirty four age- and gender matched healthy controls were enrolled. Dental examination ( dental, periodontal status) and therapy (oral health care, endodontic, surgical treatment) was performed. We have investigated the serum levels of lipid parameters ( triglicerids, cholesterol and liporpoteins), systemic inflammatory factors (CRP, IL-6, IL-1beta TNFalpha) and the PON1 activity before, one week and 3 month after the complex dental therapy. Results: After the 3 month follow up, there were significant improvements in the clinical periodontal characteristics including plaque index (PI) (p<0.01) and gingival index (GI) (p<0.05). The PON1 activity was significantly increased after three months compared to the baseline (p<0.01). There was a significant reduction in the CRP (p<0.01). There were significant differences in the microbial analysis of supragingival and subgingival plaque examination between the baseline and 3 months of follow up in reducing the pathogenic flora (p<0.01). There were no significant reductions in the serum levels of lipid parameters, IL-6 and TNF-alphalevels. There were significant differences between the control group and the patient group in the lipid parameters and the IL-1beta levels at baseline and at the follow up as well (p<0.05). Conclusions: To our knowledge, this is the first study, which investigates the effect of a complex dental therapy on PON1 activity and systemic inflammatory factors in hyperlipidemic patients. The work/publication is supported by the TÁMOP 4.2.1/B-09/1/KONV-2010-0007 project. The project is co-financed by the European Union and the European Social Fund.