Methods: In the first model, colitis was induced by intrarectal instillation of 2,4,6-trinitro benzene sulfonic acid (TNBS). In the second model, colitis was induced by feeding rats with dextran sodium sulfate (DSS) polymers in the drinking water. One week after disease induction, miniscrews were inserted into the tibia. Four weeks after implantation, peri-implant bone volume per tissue volume (BV/TV) and bone-to-implant contacts (BIC) were determined by histomorphometric analysis.
Results: Cortical histomorphometric parameters were similar in the control, DSS and TNBS groups. Cortical BV/TV was 92.2 ± 3.7%, 92.0 ± 3.0% and 92.6 ± 2.7% - and BIC was 81.3 ± 8.8%, 83.2 ± 8.4% and 84.0 ± 7.0%, respectively. Also no significant differences were observed when comparing the medullary BV/TV and BIC (19.5 ± 6.4%, 16.2 ± 5.6% and 15.4 ± 9.0%) and (48.8 ± 12.9%, 49.2 ± 6.2 and 41.9 ± 11.7%), respectively. Successful induction of colitis was confirmed by loss of body weight and morphology of the gut.
Conclusion: The results suggest that bone regeneration around implants is not impaired in chemically-induced colitis models. These findings can be considered a primer for further studies aiming to understand the cause of early implant failures in patients with Crohn's disease.