Biodegradable And Photopolymerizable Hydrogels In Dentistry

Objective: The hydrogels as high water containing materials are wildly used in biomedical, because it has tissue-like properties. The aim of this study to create a novel photoplymerizable hydrophilic material based on biodegradable polymer, as a drug delivery system. Methods: Methacryl-group attached to the polymer it can be reactive, and use a non toxic photo-initiator that it will be polymerizable with blue light. This hydrogel can load with different drugs and it will be a drug delivery system. The poly-gamma-glutamic acid (PGA) can take photo-reactive with methacryl-group and moreover it can modify with diamino compound and in this way nanoparticles were obtained. These nanoparticles can use as physically bonded filler, or it can take reactive too as the PGA. The hydrogels were studied with NMR, DLS, MTT- and LDH-tests and measured the swelling and release feature. Results: PGA based nanoparticles were obtained as the DLS results shows. A novel system can build with nanoparticles use as physically bonded filler, or chemically bond it to the matrix. The whole system and all of the components were not cytotoxic. It can state after the ~2% cytotoxicty from LDH-test, and more than 98% viability from LDH test results. These new hydrogel systems were useful drug delivery system according to a drug release measurements, and the swelling ratio was 140-160% after 24 hours. Conclusion: These hydrogels can modify with the crosslinking density of the PGA matrix, but there will be a basically potential from the nanoparticles. So this is a model system for in situ cured potentially local drug delivery devices for curing periodontal diseases. The local controlled release can raise the effectiveness of the drugs, beside the minimal applicable dose. The work is supported by the TÁMOP 4.2.1/B-09/1/KONV-2010-0007 project. The project is co-financed by the European Union and the European Social Fund.