Anti-demineralization Effect Of A Novel Fluoride-releasing Varnish On Dentin

Objectives: Recently, the increase of root caries in aging population is a crucial problem. S-PRG filler (Surface reaction type Pre-Reacted Glass-ionomer filler) has fluoride release and recharge properties. The aim of this study was to investigate anti-demineralization effect of a novel varnish containing S-PRG filler in vitro. Methods: Paired specimens were cut from bovine root dentin. One of each was used for the S-PRG group, and the other served as control (n=6). A 1×3mm test surface was made on each specimen with acid resistant varnish. The novel fluoride-releasing varnish is categorized as two bottle type self-etch adhesive. These liquids were mixed and applied on the test surface and light-cured for 10 seconds. As control, a S-PRG filler-free varnish was applied in the same way. Each specimen was immersed in 8 % methylcellulose gel demineralization system (1.5mM Ca, 0.9mM PO4, 50mM acetic acid, pH 5.0) for 7 days at 37˚C. The mineral profiles and integrated mineral loss (IML) of the lesions were obtained by transversal microradiography and analyzing software. Results: The S-PRG group exhibited significantly higher surface layer when compared with the control group. Furthermore, the S-PRG group showed significantly lower IML (3687 vol% × µm) than the control group (4392 vol% × µm) (p<0.05, Wilcoxon signed- ranks test). Conclusion: The novel fluoride-releasing varnish increased acid resistance of root dentin in the vicinity of coated surface.