Cellular Reaction to Two Types of White Mineral Trioxide Aggregate

Methods: Forty Wistar rats were used in this study. Polyethylene tubes filled with ROOT MTA or Pro Root MTA and also empty tubes serving as control were implanted into the subcutaneous tissue and harvested after 7, 15, 30, 60, and 90 days. Histologic sections were stained with hematoxylin and eosin and observed under a light microscope. Inflammatory reactions were categorized as 0 or none (without inflammatory cells), 1 or mild (inflammatory cells <25), 2 or moderate (25-125 inflammatory cells) and 3 or severe (more than 125 inflammatory cells). Statistical analyses were performed with the Kruskal-Wallis and Mann-Whitney tests. Results: Both ROOT MTA and ProRoot MTA provoked a moderate inflammatory reaction after 7 and 15 days, which significantly differed from control group (p=0.04), which provoked a mild inflammatory reaction. However, there were no significant differences at any period beyond 30 days (p>0.05). Conclusions: Based on the findings of this investigation, inflammatory cellular reaction to Root and Pro Root MTA was the same.