IADR Abstract Archives
Camellia Sinensis in Managing Oral Diseases: Systematic Review and Meta-Analysis
Objectives: To evaluate the efficacy of dental products containing tea components with other anti-microbial agents in the treatment of different oral diseases.
Methods: A systematic search of the literature using predetermined criteria to identify relevant randomised controlled trials was conducted. Studies were critically appraised using Critical Appraisal Skills Programme (CASP), Cochrane and Jadad tools. For meta-analysis, standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated for each group, then compared in multiple comparisons to identify the differences between green tea mouthwash (GTM) and chlorhexidine (CHX) mouthwash.
Results: A total of 39 studies were included in this study. GTM is comparable to Nystatin for treating denture stomatitis. Green tea (GT) lozenges increase saliva flow. GT gels and GTM improve gum health and reduce post-extraction bleeding but have limited impact on alveolar osteitis and trismus. High GT extract doses treat herpes, but not epidermolysis bullosa. GT lowers caries risk, and GT tablets reduce halitosis. No adverse effects were reported for GT preparations when used topically.
Three high-quality studies were included in the meta-analysis with a low degree of heterogeneity (I2 = 13% for Plaque Index (PI) and I2=0% for Gingival Index (GI)). Compared to CHX, GTM had a medium to high effect on PI with a significant difference found between the groups from baseline to two weeks (SMD -0.60, CI: -1.13, -0.08; P = 0.02). However, a small effect with no statistically significance on GI was reported (SMD -0.33, CI: -0.80, 0.14; P = 0.17).
Conclusions: According to the evidence available, GT preparation with no reported side effects, and may be used as alternative to traditional topical antimicrobial preparation for the prevention and management of periodontal infection, caries, halitosis, and mucosal lesions, such as denture stomatitis and herpes labialis.
Methods: A systematic search of the literature using predetermined criteria to identify relevant randomised controlled trials was conducted. Studies were critically appraised using Critical Appraisal Skills Programme (CASP), Cochrane and Jadad tools. For meta-analysis, standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated for each group, then compared in multiple comparisons to identify the differences between green tea mouthwash (GTM) and chlorhexidine (CHX) mouthwash.
Results: A total of 39 studies were included in this study. GTM is comparable to Nystatin for treating denture stomatitis. Green tea (GT) lozenges increase saliva flow. GT gels and GTM improve gum health and reduce post-extraction bleeding but have limited impact on alveolar osteitis and trismus. High GT extract doses treat herpes, but not epidermolysis bullosa. GT lowers caries risk, and GT tablets reduce halitosis. No adverse effects were reported for GT preparations when used topically.
Three high-quality studies were included in the meta-analysis with a low degree of heterogeneity (I2 = 13% for Plaque Index (PI) and I2=0% for Gingival Index (GI)). Compared to CHX, GTM had a medium to high effect on PI with a significant difference found between the groups from baseline to two weeks (SMD -0.60, CI: -1.13, -0.08; P = 0.02). However, a small effect with no statistically significance on GI was reported (SMD -0.33, CI: -0.80, 0.14; P = 0.17).
Conclusions: According to the evidence available, GT preparation with no reported side effects, and may be used as alternative to traditional topical antimicrobial preparation for the prevention and management of periodontal infection, caries, halitosis, and mucosal lesions, such as denture stomatitis and herpes labialis.