IADR Abstract Archives
Potential of a new Synthetic Carbonate Apatite Bone Substitute for Periodontal Regeneration
Abstract Body: Background
The use of various synthetic bone substitutes as a monotherapy for periodontal regeneration mainly results in a reparative healing pattern. Since xenografts or allografts are not always accepted by patients for various reasons, a synthetic alternative would be desirable.
Objective
To evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap-BS) on periodontal regeneration.
Methods
Acute-type 3-wall intrabony defects were surgically created in 4 female beagle dogs. The defects were randomly allocated and filled with CO3Ap-BS (test), deproteinized bovine bone mineral (DBBM), or left empty (control). After 8 weeks, the retrieved specimens were scanned by micro-CT and the percentages of new bone, bone substitute, and soft tissues were histologically and histometrically analyzed.
Results
Healing was uneventful in all cases without any adverse events. Formation of periodontal ligament and cementum occurred to varying extent in all groups without statistically significant differences between the groups. Residues of both bone substitutes were still present and showed integration into new bone. Histometry and micro-CT revealed that the total mineralized area or volume was higher with the use of CO3Ap-BS compared to control (66.06±9.34%, 36.11±6.40%; p=0.014 or 69.74±2.95%, 42.68±8.68%; p=0.014). The percentage of bone substitute surface covered by new bone was higher for CO3Ap-BS (47.22 ± 3.96%) than for DBBM (16.69 ± 5.66, p=0.114).
Conclusions
CO3Ap-BS and DBBM demonstrated comparable periodontal regeneration. More new bone, total mineralized area/volume, and higher osteoconductivity were observed for the CO3Ap-BS group compared to DBBM pointing to the potential of CO3Ap-BS for periodontal and bone regeneration.
The use of various synthetic bone substitutes as a monotherapy for periodontal regeneration mainly results in a reparative healing pattern. Since xenografts or allografts are not always accepted by patients for various reasons, a synthetic alternative would be desirable.
Objective
To evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap-BS) on periodontal regeneration.
Methods
Acute-type 3-wall intrabony defects were surgically created in 4 female beagle dogs. The defects were randomly allocated and filled with CO3Ap-BS (test), deproteinized bovine bone mineral (DBBM), or left empty (control). After 8 weeks, the retrieved specimens were scanned by micro-CT and the percentages of new bone, bone substitute, and soft tissues were histologically and histometrically analyzed.
Results
Healing was uneventful in all cases without any adverse events. Formation of periodontal ligament and cementum occurred to varying extent in all groups without statistically significant differences between the groups. Residues of both bone substitutes were still present and showed integration into new bone. Histometry and micro-CT revealed that the total mineralized area or volume was higher with the use of CO3Ap-BS compared to control (66.06±9.34%, 36.11±6.40%; p=0.014 or 69.74±2.95%, 42.68±8.68%; p=0.014). The percentage of bone substitute surface covered by new bone was higher for CO3Ap-BS (47.22 ± 3.96%) than for DBBM (16.69 ± 5.66, p=0.114).
Conclusions
CO3Ap-BS and DBBM demonstrated comparable periodontal regeneration. More new bone, total mineralized area/volume, and higher osteoconductivity were observed for the CO3Ap-BS group compared to DBBM pointing to the potential of CO3Ap-BS for periodontal and bone regeneration.