IADR Abstract Archives
Osteoconductive Potential and Clinical Performance of Carbonate Apatite
Abstract Body:
The use of dental implants as a therapy for the replacement of missing dentition is becoming more popular among clinicians and bone augmentation is often needed due to the lack of sufficient bone to support the implant fixture. Although various bone graft substitutes are available on the market, an ideal material for bone augmentation is yet to be determined. Synthetic carbonate apatite has been shown to increase osteoblast differentiation compared to pure hydroxyapatite bone graft substitutes. In order to understand the osteoconductive potential of carbonate apatite bone graft substitutes, we evaluated human osteoblast cells response to synthetic carbonate apatite disk compared with allograft (cortical bone plate). We evaluated osteoblastic activity using initial cell attachment, proliferation, and differentiation. Our results showed that carbonate apatite has a similar level of initial cell attachment as allograft, and cell proliferation after 7 days was higher than allograft. In the presentation, osteoconductive potential of carbonate apatite based on the in vitro evaluation, and clinical cases performed using carbonate apatite bone graft substitutes will be presented and discussed the potential clinical implications.
The use of dental implants as a therapy for the replacement of missing dentition is becoming more popular among clinicians and bone augmentation is often needed due to the lack of sufficient bone to support the implant fixture. Although various bone graft substitutes are available on the market, an ideal material for bone augmentation is yet to be determined. Synthetic carbonate apatite has been shown to increase osteoblast differentiation compared to pure hydroxyapatite bone graft substitutes. In order to understand the osteoconductive potential of carbonate apatite bone graft substitutes, we evaluated human osteoblast cells response to synthetic carbonate apatite disk compared with allograft (cortical bone plate). We evaluated osteoblastic activity using initial cell attachment, proliferation, and differentiation. Our results showed that carbonate apatite has a similar level of initial cell attachment as allograft, and cell proliferation after 7 days was higher than allograft. In the presentation, osteoconductive potential of carbonate apatite based on the in vitro evaluation, and clinical cases performed using carbonate apatite bone graft substitutes will be presented and discussed the potential clinical implications.