IADR Abstract Archives
Systematic Review of Longitudinal Associations Between Oral and Mental Disorders
Objectives: We aimed to map the existing research and critically review longitudinal studies that have examined diseases of the oral cavity in individuals with mental disorder and vice versa.
Methods: Complying with the JBI framework for scoping review, we systematically searched in MEDLINE, PsycINFO, EMBASE, Cochrane Library, and Scopus for relevant articles published during the last 20 years. Each review step is done by two reviewers independently before resolving by consensus as necessary. Covidence was used for screening and data extraction. Newcastle-Ottawa Scale was used for quality assessment. Sankey diagrams are used for presenting the main findings. The review protocol is registered with Open Science Framework: https://doi.org/10.17605/OSF.IO/VRPU9
Results: The systematic search resulted in 10,604 unique references. Upon title and abstract screening, 283 papers were selected for full text review. Exclusion reasons were mainly lack of longitudinal data (n= 84) and sub-standard definitions or misclassifications of mental or oral diseases (n=44). Thus data were extracted from 128 studies. Most studies were conducted in Taiwan (n=29, 22%), USA (n=22, 17%), Japan (n=14, 11%), South Korea (n=10, 8%), Sweden (n=8, 6%). Preliminary findings revealed that tooth loss/number of teeth, periodontitis and Sjogren’s Syndrome were the most common oral health exposures. Tooth loss was associated with dementia (n=9 studies), cognitive impairment (n=13) and depressive symptoms (n=4). Periodontitis was associated with dementia (n=7), cognitive impairment (n=6) and depression (n=4). Sjogren’s Syndrome was associated with dementia and other cognitive disorders (n=5) and depressive disorders (n=3). Fewer studies investigated mental health exposures, and they reported that depression and dysthymia were associated with increased risk of temporomandibular disorders (n=5).
Conclusions: The findings reveal evidence for potentially bidirectional causal associations between sets of oral and mental disorders highlighting niches for future investigations. Clinicians managing oral and mental health patients need to screen for coexisting conditions and provide treatment and support accordingly.
Methods: Complying with the JBI framework for scoping review, we systematically searched in MEDLINE, PsycINFO, EMBASE, Cochrane Library, and Scopus for relevant articles published during the last 20 years. Each review step is done by two reviewers independently before resolving by consensus as necessary. Covidence was used for screening and data extraction. Newcastle-Ottawa Scale was used for quality assessment. Sankey diagrams are used for presenting the main findings. The review protocol is registered with Open Science Framework: https://doi.org/10.17605/OSF.IO/VRPU9
Results: The systematic search resulted in 10,604 unique references. Upon title and abstract screening, 283 papers were selected for full text review. Exclusion reasons were mainly lack of longitudinal data (n= 84) and sub-standard definitions or misclassifications of mental or oral diseases (n=44). Thus data were extracted from 128 studies. Most studies were conducted in Taiwan (n=29, 22%), USA (n=22, 17%), Japan (n=14, 11%), South Korea (n=10, 8%), Sweden (n=8, 6%). Preliminary findings revealed that tooth loss/number of teeth, periodontitis and Sjogren’s Syndrome were the most common oral health exposures. Tooth loss was associated with dementia (n=9 studies), cognitive impairment (n=13) and depressive symptoms (n=4). Periodontitis was associated with dementia (n=7), cognitive impairment (n=6) and depression (n=4). Sjogren’s Syndrome was associated with dementia and other cognitive disorders (n=5) and depressive disorders (n=3). Fewer studies investigated mental health exposures, and they reported that depression and dysthymia were associated with increased risk of temporomandibular disorders (n=5).
Conclusions: The findings reveal evidence for potentially bidirectional causal associations between sets of oral and mental disorders highlighting niches for future investigations. Clinicians managing oral and mental health patients need to screen for coexisting conditions and provide treatment and support accordingly.