IADR Abstract Archives
Soft and Hard Tissue Changes During Long Orthodontic Tooth Movement
Objectives: The structural and compositional processing of a bone and periodontal ligament (PDL) remodeling during long-term orthodontic tooth movement (OTM) are not well described, yet. Although the mechanism of bone loss and regrowth in the directly affected alveolar bone has been deeply investigated, the exact mechanism of periodontal ligament remodeling and its relation and interaction with alveolar bone during OTM remain poorly described. This work aims to provide a deep analysis of the alveolar bone and PDL remodeling after a prolonged OTM treatment on mice.
Methods: Orthodontic force was applied using a Ni-Ti coil-spring connected to the first molar (M1) and incisor of maxillae in split-mouth mice model. After 5 weeks both sides of maxillae were scanned by high-resolution micro-CT. After precise estimation of the tooth movement, an extensive 3D analysis in two regions of the alveolar bone adjacent to M1 (i.e., M1 socket versus alveolar bone between M1 and the second molar) were performed to estimate the morphological and compositional parameters. Additionally, changes of PDL were characterized on using a novel 3D model approach.
Results: Bone loss and thinning, higher connectivity as well as lower bone mineral density were found in both studied regions, while the differences in the M1 socket were more pronounced. A non-uniformly extended PDL was observed after long OTM and characterized by an increased PDL thickness.
Conclusions: The extended and novel methodology in this study provides a comprehensive perception about the alveolar bone and PDL remodeling process after a long-duration OTM.
Methods: Orthodontic force was applied using a Ni-Ti coil-spring connected to the first molar (M1) and incisor of maxillae in split-mouth mice model. After 5 weeks both sides of maxillae were scanned by high-resolution micro-CT. After precise estimation of the tooth movement, an extensive 3D analysis in two regions of the alveolar bone adjacent to M1 (i.e., M1 socket versus alveolar bone between M1 and the second molar) were performed to estimate the morphological and compositional parameters. Additionally, changes of PDL were characterized on using a novel 3D model approach.
Results: Bone loss and thinning, higher connectivity as well as lower bone mineral density were found in both studied regions, while the differences in the M1 socket were more pronounced. A non-uniformly extended PDL was observed after long OTM and characterized by an increased PDL thickness.
Conclusions: The extended and novel methodology in this study provides a comprehensive perception about the alveolar bone and PDL remodeling process after a long-duration OTM.