IADR Abstract Archives
Cone Beam Computed Tomography for the Identification Risk of Osteoporosis.
Objectives: The aim of the study was to determine whether the mandibular cortical bone thickness, detected in cone beam computed tomography (CBCT), are affected by general bone mineral density (BMD) in postmenopausal females and to evaluate whether CBCT can be used for predicting the risk of osteoporosis.
Methods: The study included 131 postmenopausal females aged 54-87 years (average age 69.1±8.1) who underwent CBCT examinations due to dental implant planning. BMD measurements of the lumbar spine and both femoral necks were performed by dual-energy X-ray absorptiometry (DXA) and worst T-score reading from both were taken into account. CBCT images were analysed with OnDemand3D Dental software. In cross-sectional CBCT images four areas of the mandible (lateral incisor, first premolar, mental foramina, first molar) were selected to determine vestibular, lingual, and basal cortical bone width. Difference between groups was evaluated by One-way ANOVA. Performance of CBCT predicting osteoporosis was assessed by computing the area under the curve (AUC). Sensitivity (Se), specificity (Sp), PPV, NPV was calculated with dichotomous 2 × 2 tables.
Results: According to the DXA results 46 females had normal BMD, 60 had osteopenia and 25 had osteoporosis . In women with osteoporosis, cortical bone thickness was statistically significantly lower in the basal part of the mandible in all mandibular regions (lateral incisor (p=0.023), first premolar (p=0.0001), mental foramina (p=0.032) and first molar (p=0.01)). Statistically significant difference between different BMD groups was observed according to vestibular cortical bone thickness only in the incisor region (p=0.006). The basal cortical bone thickness of first premolar region showed promising diagnostic performances: AUC=0.74, Se=73.9%, SP=85%, PPV=31.9%, NPV=89.3% to predict osteoporosis.
Conclusions: Postmenopausal females with reduced BMD showed reduced cortical bone thickness in the basal part of mandible. CBCT is a promising tool for identifying postmenopausal females at increased risk of osteoporosis.
Methods: The study included 131 postmenopausal females aged 54-87 years (average age 69.1±8.1) who underwent CBCT examinations due to dental implant planning. BMD measurements of the lumbar spine and both femoral necks were performed by dual-energy X-ray absorptiometry (DXA) and worst T-score reading from both were taken into account. CBCT images were analysed with OnDemand3D Dental software. In cross-sectional CBCT images four areas of the mandible (lateral incisor, first premolar, mental foramina, first molar) were selected to determine vestibular, lingual, and basal cortical bone width. Difference between groups was evaluated by One-way ANOVA. Performance of CBCT predicting osteoporosis was assessed by computing the area under the curve (AUC). Sensitivity (Se), specificity (Sp), PPV, NPV was calculated with dichotomous 2 × 2 tables.
Results: According to the DXA results 46 females had normal BMD, 60 had osteopenia and 25 had osteoporosis . In women with osteoporosis, cortical bone thickness was statistically significantly lower in the basal part of the mandible in all mandibular regions (lateral incisor (p=0.023), first premolar (p=0.0001), mental foramina (p=0.032) and first molar (p=0.01)). Statistically significant difference between different BMD groups was observed according to vestibular cortical bone thickness only in the incisor region (p=0.006). The basal cortical bone thickness of first premolar region showed promising diagnostic performances: AUC=0.74, Se=73.9%, SP=85%, PPV=31.9%, NPV=89.3% to predict osteoporosis.
Conclusions: Postmenopausal females with reduced BMD showed reduced cortical bone thickness in the basal part of mandible. CBCT is a promising tool for identifying postmenopausal females at increased risk of osteoporosis.