IADR Abstract Archives
Assessment of Salivary Glands in Juvenile Sjogren's Syndrome
Objectives: To assess salivary gland impairment properties in a cohort of Juvenile Sjogren's syndrome (jSjS) patients.
Methods: jSjS cases were selected from records of the Sjogren’s syndrome (SjS) Center registry at the Hadassah Medical Center, Israel. Diagnosis was evaluated according to 2 set of criteria: European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification (Shibosky et al. 2016) and American-European Consensus Group Classification criteria (AECG) classification (Vitali et al. 2002). Medical evaluation included serology workout, referral to rheumatology, ophthalmology and other relevant specialties according to organs involvement.
Results: Five patients were diagnosed with jSJS according to expert opinion at mean age of 14 years. Patients presented the following findings: xerostomia (3/5), parotid swelling (2/5), xerophthalmia (3/5), positive Schirmer's test (1/5), Arthritis (2/5), Anti–SSB (La) antibodies (3/5 patients), and Rheumatoid Factor (4/5). Only 3/5 patients met the adult EULAR/ ACR SjS criteria, and 2/5 met the AECG criteria. The most significant marker was positive Anti–SSA(Ro) antibodies (5/5 patients).
Conclusions: JSjS is a rare condition, hard to diagnose and there is a need of personalized treatment approach. Systemic manifestations in the JSS patients' cohort exhibited a wide range of signs and symptoms severity, both in salivary gland impairment manifestations as well as other organ involvement. Young patients not always exhibit the same profile as older patients, and thus it is crucial to develop updated criteria for this unique group.
Methods: jSjS cases were selected from records of the Sjogren’s syndrome (SjS) Center registry at the Hadassah Medical Center, Israel. Diagnosis was evaluated according to 2 set of criteria: European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification (Shibosky et al. 2016) and American-European Consensus Group Classification criteria (AECG) classification (Vitali et al. 2002). Medical evaluation included serology workout, referral to rheumatology, ophthalmology and other relevant specialties according to organs involvement.
Results: Five patients were diagnosed with jSJS according to expert opinion at mean age of 14 years. Patients presented the following findings: xerostomia (3/5), parotid swelling (2/5), xerophthalmia (3/5), positive Schirmer's test (1/5), Arthritis (2/5), Anti–SSB (La) antibodies (3/5 patients), and Rheumatoid Factor (4/5). Only 3/5 patients met the adult EULAR/ ACR SjS criteria, and 2/5 met the AECG criteria. The most significant marker was positive Anti–SSA(Ro) antibodies (5/5 patients).
Conclusions: JSjS is a rare condition, hard to diagnose and there is a need of personalized treatment approach. Systemic manifestations in the JSS patients' cohort exhibited a wide range of signs and symptoms severity, both in salivary gland impairment manifestations as well as other organ involvement. Young patients not always exhibit the same profile as older patients, and thus it is crucial to develop updated criteria for this unique group.