IADR Abstract Archives
Comparison of 3D Bone Characteristics of MRONJ Using 2D&3D Images
Objectives: Bone characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) have not been investigated using 2D image sections. Therefore, the aim was to evaluate the trabecular changes of MRONJ patients in comparison to controls using panoramic (PR) and cone-beam computed tomography (CBCT) images.
Methods: Digital panoramic and sagittal sections of CBCT images of 24 MRONJ patients and 22 healthy controls were used for the comparison of bone area fraction (BA/TA), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N) calculations. Fraction and Slice Geometry plugins of the FiJi software were used for measurements on three regions of interest (ROIs): ROI-1 anterior and ROI-2 inferior to the mental foramen and ROI-3 superior to the mandibular canal. Comparisons of MRONJ patients and controls as well as different ROIs were done using the independent samples t-test (p<0.05).
Results: Parameters that differentiated MRONJ patients from healthy controls were BA/TA and Tb.Sp only on PR. While BA/TA values of PR were lower (p=0.002) for MRONJ patients, Tb.Sp was higher (p=0.027) than CBCT. None of the parameters and ROIs revealed any difference between patients and controls on CBCT images (p>0.05). BA/TA values of MRONJ patients calculated on PR were lower on all ROIs (p<0.05). Tb.Sp values of PR images of MRONJ patients showed higher values on ROI-1 (p=0.017) and ROI-3 (p=0.035). No difference was found between measurements of MRONJ patients and controls as well as different ROIs regarding Tb.Th and Tb.N on PR images (p>0.05). Generally, standard deviations of all parameters were higher for MRONJ patients compared to the controls, both in PR and CBCT images.
Conclusions: BA/TA and Tb.Sp can be used to differentiate trabecular bone changes of MRONJ patients in PR images. For more reliable results, ROIs 1&3 should be preferred regarding measurements of 3D bone characteristics on 2D projection images.
Methods: Digital panoramic and sagittal sections of CBCT images of 24 MRONJ patients and 22 healthy controls were used for the comparison of bone area fraction (BA/TA), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N) calculations. Fraction and Slice Geometry plugins of the FiJi software were used for measurements on three regions of interest (ROIs): ROI-1 anterior and ROI-2 inferior to the mental foramen and ROI-3 superior to the mandibular canal. Comparisons of MRONJ patients and controls as well as different ROIs were done using the independent samples t-test (p<0.05).
Results: Parameters that differentiated MRONJ patients from healthy controls were BA/TA and Tb.Sp only on PR. While BA/TA values of PR were lower (p=0.002) for MRONJ patients, Tb.Sp was higher (p=0.027) than CBCT. None of the parameters and ROIs revealed any difference between patients and controls on CBCT images (p>0.05). BA/TA values of MRONJ patients calculated on PR were lower on all ROIs (p<0.05). Tb.Sp values of PR images of MRONJ patients showed higher values on ROI-1 (p=0.017) and ROI-3 (p=0.035). No difference was found between measurements of MRONJ patients and controls as well as different ROIs regarding Tb.Th and Tb.N on PR images (p>0.05). Generally, standard deviations of all parameters were higher for MRONJ patients compared to the controls, both in PR and CBCT images.
Conclusions: BA/TA and Tb.Sp can be used to differentiate trabecular bone changes of MRONJ patients in PR images. For more reliable results, ROIs 1&3 should be preferred regarding measurements of 3D bone characteristics on 2D projection images.