Does the Integrity of Collagen Membrane Affects its Osteoconductivity?

Objectives: The aim of the present study was to compare the intact with the minced bilayer collagen membrane.
Methods: an intact or minced bilayer collagen membrane was randomly placed over a 5mm calvaria defect in Sprague Dawley rats. After three weeks of healing, ex vivo micro CT, histology, and histomorphometry were performed.
Results: we report here that the intact compared to the minced bilayer collagen membrane showed a higher median volume of 1.47mm³ (0.59 min; 5.30 max) versus 0.40 mm³ (0.08 min; 3.73 max), respectively (p=0.09). Consistently, the defect coverage was higuer in intact than in the minced bilayer collagen membrane with 42.8% (14.6 min; 84.9 max) versus 21.8% (5.3min; 74.2 max), respectively (p=0.13). We currently perform histological analysis ideally confirming that the minced bilayer collagen membrane maintain osteoconductive propoerties but require proximity to the defect margin.
Conclusions: These data suggest that the integrity of the bilayer collagen membranes affects their osteoconductive properties in rat calvaria defects.