IADR Abstract Archives
Periodontal Therapy Efficacy Impacted by Oral Bacteria in Periodontitis Patients
Objectives: The purposes of this RCT study were to compare the efficacy of two non-surgical periodontal treatment protocols (NSPT), quadrant scaling and root planning (Q-SRP) or full-mouth disinfection (FMD) in patients with periodontitis and to assess the effect of baseline periodontal bacteria on treatment regimens' protocols and clinical efficacy at a 12-month follow-up.
Methods: Eighy-one patients with stage II and III periodontitis were finally selected based on specific exclusion and inclusion criteria. The included subjects were randomly distributed for Q-SRP (n=39) or FMD (n=40) NSPT protocol. During the follow-up sessions at 1, 3, 6 and 12 months, all the included periodontal patients were assessed for probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (CAL). During the follow-up period, patients were motivated to perform personal oral hygiene. Real-time PCR was performed to quantify the mean count of some periodontal pathogens. Data were analyzed to evaluate the impact of periodontal bacteria concentrations on the efficacy of both Q-SRP and FMD.
Results: At one-year follow-up, Q-SRP was more effective than FMD on the reduction of mean PD (Q-SRP: 4.87±0.4 mm to 3.19±0.6mm; FMD, 4.91±0.5mm to 2.80±0.7mm) and the mean proportion of Tannerella forsythus, Porphyromonas gingivalis (Pg) and Actinobacillus actinocomyctemcomitans (Aa). The multivariate linear regression analysis showed that the baseline Pg (p=0.006), Aa (p=0.014) levels and the Q-SRP protocol (p= 0.028) were significant predictors of the mean PD reduction (p=0.019). Furthermore, the PD and BOP reduction was higher in the Q-SRP group when there was a low baseline Aa mean count.
Conclusions: At 12-month follow-up, the Q-SRP protocol was more effective than FMD in reducing clinical and microbiological mediator changes in patients with periodontitis. Furthermore, baseline Aa and Pg levels impacted the efficacy of both NSPT protocols, with a more significant impact in the Q-SRP group.
Methods: Eighy-one patients with stage II and III periodontitis were finally selected based on specific exclusion and inclusion criteria. The included subjects were randomly distributed for Q-SRP (n=39) or FMD (n=40) NSPT protocol. During the follow-up sessions at 1, 3, 6 and 12 months, all the included periodontal patients were assessed for probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (CAL). During the follow-up period, patients were motivated to perform personal oral hygiene. Real-time PCR was performed to quantify the mean count of some periodontal pathogens. Data were analyzed to evaluate the impact of periodontal bacteria concentrations on the efficacy of both Q-SRP and FMD.
Results: At one-year follow-up, Q-SRP was more effective than FMD on the reduction of mean PD (Q-SRP: 4.87±0.4 mm to 3.19±0.6mm; FMD, 4.91±0.5mm to 2.80±0.7mm) and the mean proportion of Tannerella forsythus, Porphyromonas gingivalis (Pg) and Actinobacillus actinocomyctemcomitans (Aa). The multivariate linear regression analysis showed that the baseline Pg (p=0.006), Aa (p=0.014) levels and the Q-SRP protocol (p= 0.028) were significant predictors of the mean PD reduction (p=0.019). Furthermore, the PD and BOP reduction was higher in the Q-SRP group when there was a low baseline Aa mean count.
Conclusions: At 12-month follow-up, the Q-SRP protocol was more effective than FMD in reducing clinical and microbiological mediator changes in patients with periodontitis. Furthermore, baseline Aa and Pg levels impacted the efficacy of both NSPT protocols, with a more significant impact in the Q-SRP group.