IADR Abstract Archives
Effects of Calcium Silicates on Pulp Inflammation and Regeneration
Abstract Body: Pulp healing/regeneration following pathological conditions represents a real challenge in the provision of a suitable treatment that ideally leads to the induction of the dentin-pulp regeneration. However, the pulp response to tooth traumatic injury/carious lesions is highly dependent on the pulp inflammatory degree mainly due to its location within rigid dentinal walls. Thus, while the initial inflammation represents a pre-requisite for pulp healing, a rapid resolution of inflammation would favor the regenerative process which is key for a successful clinical outcome.
Recent data have shown that injured pulp fibroblasts, which occurs under carious/traumatic injury, provide a series of biologically active molecules via Complement system activation. Among these active molecules, C5b and C5b-9 are involved in the local control of infection by killing cariogenic bacteria directly and inducing their elimination by phagoytosis. Other molecules such as C3a and C5a have shown a clear implication in pulp stem cell activation, proliferation and recruitment. These data clearly demonstrate that, upon injury, the pulp fibroblast exert a local control of the initial steps of inflammation and regeneration.
In addition, the pulp cells control the inflammatory reaction by secreting multiple cytokines and growth factors that affect the balance between pulp inflammation and regeneration. Application of tricalcium silicate-based materials directly onto the pulp has been shown to modulate the inflammatory activity by decreasing pro-inflammatory factors and inflammatory cell recruitment. At the same time, the materials’ hydration/by-products release and their interaction with the soft tissues induce stem cell proliferation and recruitment, thus, shifting the tissue response towards regeneration.
This presentation will explain how a good knowledge of bioactive tricalcium silicates properties combined with the pulp anti-inflammatory/regeneration potentials can provide a rational in symptomatic carious exposure treatment as well as pulp exposure.
Recent data have shown that injured pulp fibroblasts, which occurs under carious/traumatic injury, provide a series of biologically active molecules via Complement system activation. Among these active molecules, C5b and C5b-9 are involved in the local control of infection by killing cariogenic bacteria directly and inducing their elimination by phagoytosis. Other molecules such as C3a and C5a have shown a clear implication in pulp stem cell activation, proliferation and recruitment. These data clearly demonstrate that, upon injury, the pulp fibroblast exert a local control of the initial steps of inflammation and regeneration.
In addition, the pulp cells control the inflammatory reaction by secreting multiple cytokines and growth factors that affect the balance between pulp inflammation and regeneration. Application of tricalcium silicate-based materials directly onto the pulp has been shown to modulate the inflammatory activity by decreasing pro-inflammatory factors and inflammatory cell recruitment. At the same time, the materials’ hydration/by-products release and their interaction with the soft tissues induce stem cell proliferation and recruitment, thus, shifting the tissue response towards regeneration.
This presentation will explain how a good knowledge of bioactive tricalcium silicates properties combined with the pulp anti-inflammatory/regeneration potentials can provide a rational in symptomatic carious exposure treatment as well as pulp exposure.