IADR Abstract Archives
Periodontal Diseases Increase the Oral Chronic Graft-Versus-Host Disease Occurrence
Objectives: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic stem cell transplant (HSCT). The cGVHD commonly affects the mouth that leads to an alteration of the patient's quality of life and a potential malnutrition.
The aim of this study is to evaluate the impact of oral factors on the development of oral cGVHD in patients who are candidate for HSCT for hematological malignancies.
Methods: An observational, retrospective, monocentric study was carried out in the Odontology Department of the CHU of Lille from February 2018 to March 2020. Both general factors (age, histocompatibility, allograft origin, conditioning treatment, hemopathy, preventive treatment) and oral factors (xerostomia, salivary pH, dental metal or resin filling, decay, apical infectious focus, periodontal disease) have been evaluated in order to determine their influence on cGVHD occurring.
Results: On 109 patients who are candidates for HSCT, 27 were excluded (dead at 3 months after HSCT or cancelled HSCT) and 11 were lost during the dental follow-up. Of the 71 patients, 22 developed oral cGVHD. The study showed that periodontal disease significantly differs between the cGVHD group and the no cGVHD group (p=0.0145), even if the periodontal disease factor was adjusted with known general factors as age, histocompatibility and allograft origin (p=0.0389). The periodontal disease factor significantly increased 4.173 times the risk of oral cGVHD occurrence.
Conclusions: These results highlight the relationships between the state of the oral cavity and the susceptibility to develop oral cGVHD. Collaboration between the hematologist and the dental surgeon is necessary to ensure good oral hygiene and a reduction in the inflammatory state of the oral cavity, and thus prevent the development of oral cGVHD.
The aim of this study is to evaluate the impact of oral factors on the development of oral cGVHD in patients who are candidate for HSCT for hematological malignancies.
Methods: An observational, retrospective, monocentric study was carried out in the Odontology Department of the CHU of Lille from February 2018 to March 2020. Both general factors (age, histocompatibility, allograft origin, conditioning treatment, hemopathy, preventive treatment) and oral factors (xerostomia, salivary pH, dental metal or resin filling, decay, apical infectious focus, periodontal disease) have been evaluated in order to determine their influence on cGVHD occurring.
Results: On 109 patients who are candidates for HSCT, 27 were excluded (dead at 3 months after HSCT or cancelled HSCT) and 11 were lost during the dental follow-up. Of the 71 patients, 22 developed oral cGVHD. The study showed that periodontal disease significantly differs between the cGVHD group and the no cGVHD group (p=0.0145), even if the periodontal disease factor was adjusted with known general factors as age, histocompatibility and allograft origin (p=0.0389). The periodontal disease factor significantly increased 4.173 times the risk of oral cGVHD occurrence.
Conclusions: These results highlight the relationships between the state of the oral cavity and the susceptibility to develop oral cGVHD. Collaboration between the hematologist and the dental surgeon is necessary to ensure good oral hygiene and a reduction in the inflammatory state of the oral cavity, and thus prevent the development of oral cGVHD.