IADR Abstract Archives

Salivary Macrophage Activation-Related Cytokines in Children With Type1 Diabetes Mellitus

Objectives: Type 1 diabetes mellitus (T1DM) is related to the increased prevalence and severity of periodontitis and also impairs macrophage recruitment and differentiation. The aim of this cross-sectional study was to evaluate the salivary concentration of macrophage activation-related cytokines in children with and without T1DM in relation to periodontal status.
Methods: A total of 151 children (78 with T1DM and 73 systemically healthy) between 3-15 years-old were included in the study (Ethical permission number: E-71522473-050.01.04-15422). Unstimulated salivary samples were collected from all participants before dental and periodontal examinations. Salivary interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein (MCP)-1, MCP-2, MCP-3, MCP-4, macrophage-derived chemokine (MDC), macrophage migration inhibitory factor (MIF), monokine induced by IFN-gamma (MIG) and, macrophage inflammatory protein-1 alpha (MIP-1α) concentrations were quantified using the Luminex® xMAP™ technique. All statistical analyses were run by a commercially available software (IBM SPSS Statistics for Windows, version 22.0, IBM Corp., Armonk, NY, USA)
Results: Plaque index (PI%) and bleeding on probing (BOP%) were found significantly higher in individuals with T1DM while healthy group exhibited higher Decayed, Missing, Filled Teeth Index (DMFT) score. T1DM group demonstrated higher concentrations of salivary MCP-1 (p=0.003), MCP-3 (p<0.001), MIG (p=0.018) and, MIP-1α (p=0.016) compared to healthy individuals while the concentrations of MCP-2 (p=0.018) and, MCP-4 (p<0,001) were statistically higher in control group. After adjusting for age, PI%, BOP% and DMFT, significant differences in salivary MCP-1, MCP-2, MCP-4, and MIP-1α concentrations were observed between T1DM and control groups.
Conclusions: In conclusion, our results demonstrate that T1DM disrupts the salivary macrophage activation-related cytokine profile in children. These findings can be an outcome of the impaired systemic immune response in T1DM.

2021 Continental European and Scandinavian Divisions Meeting (Brussels, Belgium, Hybrid)
Brussels, Belgium, Hybrid
2021
0146
Periodontal Research-Pathogenesis
  • Kaya Yilmaz, Neslihan  ( Institute of Dentistry, University of Turku , Turku , Finland ;  Faculty of Dentistry, Sakarya University , Sakarya , Turkey )
  • Yilmaz, Dogukan  ( Faculty of Dentistry, Sakarya University , Sakarya , Turkey )
  • Gül Aydin, Elif  ( Faculty of Dentistry, Sakarya University , Sakarya , Turkey )
  • Polat, Recep  ( Faculty of Medicine, Sakarya University , Sakarya , Turkey )
  • Gürsoy, Mervi  ( Institute of Dentistry, University of Turku , Turku , Finland )
  • Gursoy, Ulvi  ( Institute of Dentistry, University of Turku , Turku , Finland )
  • NONE
    Oral Session VIRTUAL
    Periodontology